{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:45:42Z","timestamp":1762641942537},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EB 00246\u201020"],"award-info":[{"award-number":["EB 00246\u201020"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A family of pH\u2010responsive terpolymers composed of methacrylic acid (MAA), <jats:italic>N<\/jats:italic>\u2010vinyl pyrrolidone (NVP), and poly(ethylene glycol) monomethylether monomethacrylate (PEGMMA) have been developed and evaluated for their pH\u2010responsive swelling behavior, protein\u2010loading capabilities, and cytocompatibility. These terpolymer hydrogels, designated as P((MAA\u2010co\u2010NVP)\u2010<jats:italic>g<\/jats:italic>\u2010EG), were synthesized with varying PEG chain lengths and monomer feed ratios. The incorporation of MAA into the terpolymer structure was quantified with potentiometric titration. Equilibrium and dynamic swelling studies confirmed the pH\u2010responsive behavior of the hydrogel, with the system remaining collapsed\/complexed in acidic pH conditions and swollen\/decomplexed in neutral pH conditions. The ability of the hydrogels to partition protein into the swollen network was assessed for two model proteins of varying molecular weight: insulin and porcine growth hormone. Finally, the cytocompatibility of the hydrogels in the presence of two model intestinal cell lines was investigated and confirmed minimal cytotoxicity at and below 2.5 mg\/mL. The developed P((MAA\u2010co\u2010NVP)\u2010<jats:italic>g<\/jats:italic>\u2010EG) hydrogels exhibit unique properties that could potentially be utilized for drug delivery and separation applications. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1243\u20131251, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36030","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T16:12:46Z","timestamp":1486570366000},"page":"1243-1251","source":"Crossref","is-referenced-by-count":10,"title":["Student Award for Outstanding Research Winner in the Undergraduate Category for the 2017 Society for Biomaterials Annual Meeting and Exposition, April 5\u20138, 2017, Minneapolis, Minnesota: Development and characterization of stimuli\u2010responsive hydrogel microcarriers for oral protein delivery"],"prefix":"10.1002","volume":"105","author":[{"given":"Colleen","family":"O'Connor","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The University of Texas at Austin 107 West Dean Keeton Street Stop C0800 Austin Texas 78712"},{"name":"Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, The University of Texas at Austin 107 West Dean Keeton Street Stop 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