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Gamma irradiation was mainly introduced in this work as an effective sterilizing technique, improvement of bulk properties and surface modification of glass. Where, gamma irradiation is considered a modifier for glass network due to generation of defects resulted from this irradiation. Furthermore, SrO was introduced into the glass structure in place of Na<jats:sub>2<\/jats:sub>O in order to reduce a probable toxic effect of Na<jats:sub>2<\/jats:sub>O for surrounding tissue by decreasing its percentage. Where, Sr<jats:sup>2+<\/jats:sup> is characterized by its antibacterial properties, as well as, it induces formation of bone tissue and inhibits its resorption. The cell viability was studied for selected samples using Vero cells. As well as, antimicrobial activity was evaluated against <jats:italic>Bacillus subtilis, Staphylococcus pneumonia,<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic> bacteria. The results showed that substitution of Na<jats:sub>2<\/jats:sub>O by SrO in glass composition decreased the glass dissolution in SBF. However, the glass dissolution increased after irradiation of such glass due to generation of nonbridgingoxygens (NBOs) throughout glass network by gamma irradiation, and this effect was more obvious for Sr\u2010contained glass. On the other hand, two selected Sr\u2010containing glasses (gamma irradiated at 0 and 25 kGy) showed a good ability to stimulate cell proliferation of normal fibroblast cells, as well as, they represented a potential ability to inhibit the growth of or kill bacteria, which is considered an important issue commonly found in a clinical situation. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1646\u20131655, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36035","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T22:46:44Z","timestamp":1486766804000},"page":"1646-1655","source":"Crossref","is-referenced-by-count":22,"title":["Study of the dual effect of gamma irradiation and strontium substitution on bioactivity, cytotoxicity, and antimicrobial properties of 45S5 bioglass"],"prefix":"10.1002","volume":"105","author":[{"given":"M. M.","family":"Farag","sequence":"first","affiliation":[{"name":"Glass Research Department National Research Center, 33 El\u2010Bohooth St, Dokki Giza 1262 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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