{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:37:05Z","timestamp":1791401825815,"version":"4.3.3"},"reference-count":179,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite the growing number of publications in the field of implant dentistry, there are limited studies to date investigating the biology and metabolism of bone healing around dental implants and their implications in peri\u2010implant marginal bone loss. The aim of this review article is to provide a thorough understanding of the biological events taking place during osseointegration and the subsequent early and late phases of bone remodeling around dental implants. An update on the coupling mechanism occurring during bone resorption\u2010bone remodeling is provided, focused on the relevance of the osteocytes, bone lining cells and immune cells during bone maintenance. An electronic and manual literature search was conducted by three independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles up to September 2016 with no language restriction. Local bone metabolism is subject to signals from systemic calcium\u2010phosphate homeostasis and bone remodeling. Three areas of interest were reviewed due to recent reported compromises in bone healing including the putative effects of (1) cholesterol, (2) hyperlipidemia, and (3) low vitamin D intake. Moreover, the prominent influence of osteocytes and immune cells is discussed as being key regulators during dental implant osseointegration and maintenance. These cells are of crucial importance in the presence of biofilm accumulation and their associated byproducts that leads to hard and soft tissue breakdown; the so called peri\u2010implantitis. Factors that could negatively impact osteoclastogenesis or osteal macrophage activation should be monitored in future research including implant placement\/torque protocols, bone characteristics, as well as meticulous maintenance programs to favor osseointegration and future long\u2010term stability and success of dental implants. \u00a9 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2075\u20132089, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36060","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T21:19:02Z","timestamp":1489094342000},"page":"2075-2089","source":"Crossref","is-referenced-by-count":227,"title":["Basis of bone metabolism around dental implants during osseointegration and peri\u2010implant bone loss"],"prefix":"10.1002","volume":"105","author":[{"given":"Angel","family":"Insua","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Monje","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hom\u2010Lay","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine The University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Miron","sequence":"additional","affiliation":[{"name":"Department of Periodontology Nova Southeastern University Fort Lauderdale Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2003.67.8.tb03681.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028006517.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01837.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12636"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12274"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-003-0002-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04151206"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/421746"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.320"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20603"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091980204"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91273-8"},{"key":"e_1_2_10_14_1","first-page":"953","article-title":"Bone lining cells: Structure and function","volume":"3","author":"Miller SC","year":"1989","journal-title":"Scanning Microsc"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(86)90255-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2474"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.11.1760"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i3.40"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100609"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.1.77"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/35015116"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.10.009"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409454"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00241-0"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90452-3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.08.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.09.010"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.10.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081210"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.08.121"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2936"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080216"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12503"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.2.115"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<250::AID-ANR3>3.0.CO;2-P"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12223"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514551754"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/742439"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.10.1372"},{"key":"e_1_2_10_41_1","first-page":"1","article-title":"Accuracy of Schneiderian membrane thickness: A cone\u2010beam computed tomography analysis with histological validation","author":"Insua A","year":"2016","journal-title":"Clin Oral Implants Res."},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revsto.2015.11.004"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10024-1952"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34709"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090178"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32945"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-016-1734-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.32786"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515622432"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089343"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01895.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514566029"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00236-2"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.01.025"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.5.907"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00123.x"},{"key":"e_1_2_10_57_1","first-page":"39","article-title":"Bone classification, training keys to implant success","volume":"8","author":"Misch CE.","year":"1989","journal-title":"Dent Today"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150263"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(97)00073-2"},{"key":"e_1_2_10_60_1","first-page":"69111","volume-title":"Basic Orthopaedic Biomechanics","author":"Hayes WC","year":"1997"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.11.022"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.03.006"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12398"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02550.x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01022.x"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01679.x"},{"key":"e_1_2_10_67_1","first-page":"769","article-title":"Correlation between placement torque and survival of single\u2010tooth implants","volume":"20","author":"Ottoni JM","year":"2005","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12337"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2011.00351.x"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12268"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12390"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12448"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.06.007"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.013"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0000000000000457"},{"key":"e_1_2_10_76_1","first-page":"425","article-title":"The acceleration of titanium implant osseointegration by low intensity pulsed ultrasound: An experimental study in rats","volume":"46","author":"Zhou HB","year":"2011","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.01083"},{"key":"e_1_2_10_78_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-0039-1697389","article-title":"Effects of low\u2010intensity pulsed ultrasound on dental implant osseointegration: a preliminary report","volume":"2","author":"Ustun Y","year":"2008","journal-title":"Eur J Dent"},{"key":"e_1_2_10_79_1","first-page":"1","article-title":"Effects of low\u2010frequency ultrasound treatment of titanium surface roughness on osteoblast phenotype and maturation","author":"Sedlaczek J","year":"2016","journal-title":"Clin Oral Implants Res."},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836..t01-6-.x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.134001"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100176"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01019.x"},{"key":"e_1_2_10_84_1","first-page":"425","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue. Part 3: A histologic study in monkeys","volume":"15","author":"Miyata T","year":"2000","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_10_85_1","first-page":"384","article-title":"The influence of controlled occlusal overload on peri\u2010implant tissue. part 4: A histologic study in monkeys","volume":"17","author":"Miyata T","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01360.x"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3793"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70007-5"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.150330"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01824.x"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12417"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.44.5.842"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJR.0b013e3282f3c76b"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.216309"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-014-0199-y"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2014.02.013"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2015.06.002"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.06.027"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.02.012"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20101939"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-011-0345-x"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3074"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24487"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.09.016"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K07E-004"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070181"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230719"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1189731"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M063354"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12216"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.10.106"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00105"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2016.42.4.187"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/953241"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0334"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-13-00062"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2011.09.030"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-009-0084-4"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.20927"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45890"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.11.6433"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12641"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-849X.2009.00446.x"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095689"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12707"},{"key":"e_1_2_10_127_1","article-title":"Osseoinductive elements around immediate implants for better osteointegration: a pilot study in foxhound dogs","author":"Salomo\u2010Coll O","journal-title":"Clin Oral Implants Res."},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5319718"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00618-8"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01923.x"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2011.10.002"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.09.020"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.017"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(00)00132-X"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200305000-00006"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0284-1"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-007-0004-2"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V82260"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.05.019"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12179"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514549378"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01544.x"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.06.027"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1080\/17453670610045902"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.12.017"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B2 .9730"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1159\/000074546"},{"key":"e_1_2_10_149_1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/jbm.a.32587","article-title":"Bone formation on rough, but not polished, subcutaneously implanted Ti surfaces is preceded by macrophage accumulation","volume":"93","author":"Chehroudi B","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.11607\/jomi.te55"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.03.013"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.66.1.189"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.2.1232"},{"key":"e_1_2_10_154_1","first-page":"553","article-title":"Primer on the Metabolic Bone Disease and Disorders of Mineral Metabolism","volume":"37","author":"Favus MJ.","year":"1996","journal-title":"Revue Francaise d Endocrinologie Clinique Nutrition Et Metabolisme"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.08.128"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2448"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.12703\/P6-13"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.323"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000371"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1012512"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.017"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.05.002"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02325.x"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34666"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012875.x"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12142"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12274"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.01.004"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.2741\/2692"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.10.035"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12376"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.4103\/2231-0746.119221"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1563\/AAID-JOI-D-14-00273"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.10.011"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2013.0633"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.08.018"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.07.041"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0502.102969"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000026421.61398.F2"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.36060","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.36060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T18:29:18Z","timestamp":1719080958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.36060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":179,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/jbm.a.36060"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.36060","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}