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In the first step, four\u2010armed PEG was modified with <jats:italic>N<\/jats:italic>\u2010hydroxysuccinimide (NHS)\u2010activated esters and thereafter, crosslinked by selenocystamine crosslinkers to form injectable hydrogels via the rapid reaction between NHS\u2010activated esters and amino groups. The cross\u2010sectional morphology, mechanical properties, and crosslinking modes of hydrogels were well characterized via scanning electron microscope (SEM), rheological measurements, and Fourier transform infrared spectra, respectively. In addition, the oxidation\u2010 and reduction\u2010responsive degradation behaviors of hydrogels were observed and analyzed. The model drug, rhodamine B, was encapsulated in the hydrogel. The drug\u2010loaded hydrogel exhibited a dual redox responsive release profile, which was consistent with the degradation experiments. The results of all experiments indicated that the formulated injectable dual redox responsive diselenide\u2010containing PEG hydrogel can have potential applications in various biomedical fields such as drug delivery and stimuli\u2010responsive drug release. \u00a9 2017 Wiley Periodicals, Inc. 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