{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:34:11Z","timestamp":1768746851901,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200809"],"award-info":[{"award-number":["81200809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The surface modification of titanium and its alloys with amino group plasma\u2010enhanced chemical vapor deposition has been proven to enhance the performance of implants on initial osteoblast bioactivity in vitro. However, scarce information on the effect of this kind of surface modification on nerve regeneration exists. In this study, the surface chemistry of pure Ti disks and surface\u2010modified disks was examined using X\u2010ray photoelectron spectroscopy. Cell counting kit 8 assay, 4,6\u2010diamidino\u20102\u2010phenylindole staining, flow cytometry, and scanning electron microscopy showed that either the p30% or cw\u2009+\u2009p30% mode\u2010mediated surface significantly promote Schwann cell adhesion without any cytotoxicity compared with the pure Ti surface, and the cw\u2009+\u2009p30% group showed the best performance on cell adhesion. However, results of polymerase chain reaction and Western blot analyses showed that the mRNA and protein levels of glial cell\u2010derived neurotrophic factor and nerve growth factor of the p30% and cw\u2009+\u2009p30% groups were lower than those of the Ti group at some time points. Generally, the results indicate that amino\u2010functionalized Ti surfaces can promote Schwann cell adhesion without cytotoxicity, but this modification, in fact, inhibited the expression of the key growth factors GDNF and NGF of Schwann cells. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 265\u2013271, 2018.<\/jats:p>","DOI":"10.1002\/jbm.a.36167","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:16:49Z","timestamp":1502093809000},"page":"265-271","source":"Crossref","is-referenced-by-count":12,"title":["The effect of amino plasma\u2010enhanced chemical vapor deposition\u2010treated titanium surface on Schwann cells"],"prefix":"10.1002","volume":"106","author":[{"given":"Jinghui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"},{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dental Implantology School and Hospital of Stomatology, Ji Lin University Changchun People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1877610801002010040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1504\/IJNBM.2007.016517"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000178118.38667.9b"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpr.2002.128128"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(00)70134-X"},{"key":"e_1_2_8_7_1","first-page":"412","article-title":"Bone response to surface\u2010modified titanium implants: studies on the early tissue response to implants with different surface characteristics. 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