{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:35:07Z","timestamp":1768977307620,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T00:00:00Z","timestamp":1505260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ellenburg Chair in Surgery at Stanford University","award":["2R01AR055650"],"award-info":[{"award-number":["2R01AR055650"]}]},{"name":"Ellenburg Chair in Surgery at Stanford University","award":["1R01AR063717"],"award-info":[{"award-number":["1R01AR063717"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excessive production of wear particles from total joint replacements induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the transcription factor NF\u2010\u03baB. We previously demonstrated that inhibition of NF\u2010\u03baB signaling by using the decoy oligodeoxynucleotide (ODN) mitigates polyethylene wear particle\u2010induced bone loss using in vitro and in vivo models. However, the mechanisms of NF\u2010\u03baB decoy ODN action, and in particular its impact on systemic macrophage recruitment, remain unknown. In the current study, this systemic macrophage infiltration was examined in our established murine femoral continuous particle infusion model. RAW264.7 murine macrophages expressing a luciferase reporter gene were injected into the systemic circulation. Quantification of bioluminescence showed that NF\u2010\u03baB decoy ODN reduced the homing of these reporter macrophages into the distal femurs exposed to continuous particle delivery. Particle\u2010induced reduction in bone mineral density at the distal diaphysis of the femur was also mitigated by infusion of decoy ODN. Histological staining showed that the decoy ODN infusion decreased osteoclast and macrophage numbers, but had no significant effects on osteoblasts. Local infusion of NF\u2010\u03baB decoy ODN reduced systemic macrophage infiltration and mitigated particle\u2010induced bone loss, thus providing a potential strategy to treat periprosthetic osteolysis. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3169\u20133175, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36169","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:02:45Z","timestamp":1502092965000},"page":"3169-3175","source":"Crossref","is-referenced-by-count":14,"title":["Orthopaedic wear particle\u2010induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF\u2010\u03baB decoy oligodeoxynucleotide"],"prefix":"10.1002","volume":"105","author":[{"given":"Tzuhua","family":"Lin","sequence":"first","affiliation":[{"name":"Departments of Orthopaedic Surgery Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Pajarinen","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedic Surgery Stanford University Stanford 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