{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:19:45Z","timestamp":1773868785355,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271036"],"award-info":[{"award-number":["31271036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Investigating the effect of four types of artificial nerve graft (ANG) structures on rat sciatic nerve defect repair will aid future ANG designs. In this study, fibroin fibers and polylactic acid were used to prepare four ANGs with differing structures: nerve conduit with micron\u2010sized pores (Conduit with pore group), nerve conduit without micron\u2010sized pores (Conduit group), nerve scaffold comprising Conduit with pore group material plus silk fibers (Scaffold with pore group), and nerve scaffold comprising Conduit group material plus silk fibers (Scaffold group). ANGs or autologous nerves (Autologous group) were implanted into 10 mm rat sciatic nerve defects (n\u2009=\u200950 per group). Twenty weeks after nerve grafting, the time required to retract the surgical limb from the hot water was ranked as follows: Conduit with pore group\u2009&gt;\u2009Scaffold with pore group\u2009&gt;\u2009Conduit group\u2009&gt;\u2009Scaffold group\u2009&gt;\u2009Autologous group. The static sciatic index was ranked in descending order: Autologous group\u2009&gt;\u2009Scaffold group\u2009&gt;\u2009Conduit group\u2009&gt;\u2009Scaffold with pore group\u2009&gt;\u2009Conduit with pore group. Immunofluorescence staining identified significant differences in the distribution and number of axons, Schwann cells, and fibroblasts. These findings indicate that ANGs with micron\u2010sized pores had a negative impact on the repair of peripheral nerve defects, while internal microchannels were beneficial. \u00a9 2017 The Authors. Journal of Biomedical Materials Research Part A Published by Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3077\u20133085, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36172","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T08:02:39Z","timestamp":1502092959000},"page":"3077-3085","source":"Crossref","is-referenced-by-count":13,"title":["The effect of four types of artificial nerve graft structures on the repair of 10\u2010mm rat sciatic nerve gap"],"prefix":"10.1002","volume":"105","author":[{"given":"Chan","family":"Zhou","sequence":"first","affiliation":[{"name":"Chongqing Academy of Animal Science Chongqing 400015 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Freshwater Fish Reproduction and Development, Ministry of Education, School of Life Sciences Southwest University Chongqing 400715 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