{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:04:09Z","timestamp":1792782249779,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T00:00:00Z","timestamp":1503532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NSF ERC for Revolutionizing Metallic Biomaterials","award":["EEC-0812348"],"award-info":[{"award-number":["EEC-0812348"]}]},{"name":"NSF ERC for Revolutionizing Metallic Biomaterials","award":["NCAT 260116 C"],"award-info":[{"award-number":["NCAT 260116 C"]}]},{"name":"American Association of Hand Surgeons, Annual Research Grant; University of Cincinnati Department of Otolaryngology-Head and Neck Surgery"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A current clinical challenge is to replace autografts for repair of injury gaps in peripheral nerves, which can occur due to trauma or surgical interruption. Biodegradable metallic magnesium filaments, placed inside hollow nerve conduits, could support nerve repair by providing contact guidance support for axonal regeneration. This was tested by repairing sciatic nerves of adult rats with single magnesium filaments placed inside poly(caprolactone) nerve conduits. Controls were empty conduits, conduits containing titanium filaments and\/or isografts from donor rats. With a nerve gap of 6 mm and 6 weeks post\u2010repair, magnesium filaments had partially resorbed. Regenerating cells had attached to the filaments and axons were observed in distal stumps in all animals. Axon parameters were improved with magnesium compared to conduits alone or conduits with single titanium filaments. With a longer gap of 15 mm and 16 weeks post\u2010repair, functional parameters were improved with isografts, but not with magnesium filaments or empty conduits. Magnesium filaments were completely resorbed and no evidence of scarring was seen. While axon outgrowth was not improved with the longer gap, histological measures of the tissues were improved with magnesium compared to empty conduits. Therefore, the use of magnesium filaments is promising because they are biocompatible and improve aspects of nerve regeneration. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3148\u20133158, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36176","type":"journal-article","created":{"date-parts":[[2017,8,7]],"date-time":"2017-08-07T04:06:39Z","timestamp":1502078799000},"page":"3148-3158","source":"Crossref","is-referenced-by-count":51,"title":["<scp>S<\/scp>\n                    hort and long gap peripheral nerve repair with magnesium metal filaments"],"prefix":"10.1002","volume":"105","author":[{"given":"Tracy M.","family":"Hopkins","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Little","sequence":"additional","affiliation":[{"name":"Division of Pediatric Orthopaedics Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave Cincinnati Ohio 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Vennemeyer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson L.","family":"Triozzi","sequence":"additional","affiliation":[{"name":"Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Turgeon","sequence":"additional","affiliation":[{"name":"Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Heilman","sequence":"additional","affiliation":[{"name":"Student Affairs, University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Minteer","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Pittsburgh 3380 Boulevard of the Allies, Suite 138, Pittsburgh Pennsylvania 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Marra","sequence":"additional","affiliation":[{"name":"Departments of Plastic Surgery and Bioengineering, 1655E BST University of Pittsburgh 200 Lothrop St., Pittsburgh Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Hom","sequence":"additional","affiliation":[{"name":"Division of Facial Plastic &amp; Reconstructive Surgery, Department of Otolaryngology\u2010Head and Neck Surgery University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Pixley","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Systems Physiology University of Cincinnati College of Medicine, 231 Albert Sabin Way Cincinnati Ohio 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.10.002"},{"key":"e_1_2_7_3_1","first-page":"533","article-title":"Clinical applications of autografts, conduits, and allografts in repair of nerve defects in the hand: Current guidelines. 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