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We hypothesized that polyester patches heal by infiltration of arterial or venous progenitor cells depending on the site of implantation. Polyester patches were implanted into the Wistar rat aorta or inferior vena cava and explanted on day 7 or 30. Neointima that formed on polyester patches was thicker in the venous environment compared to the amount that formed on patches in the arterial environment. Venous patches had more cell proliferation and greater numbers of VCAM\u2010positive and CD68\u2010positive cells, whereas arterial patches had greater numbers of vimentin\u2010positive and alpha\u2010actin\u2010positive cells. Although there were similar numbers of endothelial progenitor cells in the neointimal endothelium, cells in the arterial patch were Ephrin\u2010B2\u2010 and notch\u20104\u2010positive while those in the venous patch were Eph\u2010B4\u2010 and COUP\u2010TFII\u2010positive. Venous patches treated with an arteriovenous fistula had decreased neointimal thickness; neointimal endothelial cells expressed Ephrin\u2010B2 and notch\u20104 in addition to Eph\u2010B4 and COUP\u2010TFII. Polyester patches in the venous environment acquire venous identity, whereas patches in the arterial environment acquire arterial identity; patches in the fistula environment acquire dual arterial\u2010venous identity. These data suggest that synthetic patches heal by acquisition of identity of their environment. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3422\u20133431, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36193","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:01:23Z","timestamp":1504717283000},"page":"3422-3431","source":"Crossref","is-referenced-by-count":30,"title":["Polyester vascular patches acquire arterial or venous identity depending on their environment"],"prefix":"10.1002","volume":"105","author":[{"given":"Hualong","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Physiology Basic Medical College of Zhengzhou University Henan China"},{"name":"The Vascular Biology and Therapeutics Program Yale University School of Medicine New Haven Connecticut"},{"name":"Department of Surgery Yale University School of Medicine New Haven Connecticut"},{"name":"Department of Vascular Surgery First Affiliated Hospital of Zhengzhou University  Henan 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