{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:53:11Z","timestamp":1789779191343,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This work reports the biocompatibility evaluation of cyclic olefin copolymers (COC) as candidates for implantable medical devices. The focus was to establish the influence of two major additives (antioxidant and lubricant) on the overall biocompatibility.<\/jats:p><jats:p>The cytotoxicity was evaluated according to ISO 10993\u20105 guidelines using L929 fibroblasts, HUVEC, and THP\u20101\u2010derived macrophages. Oxidative stress (ROS, GSH\/GSSG, and SOD analysis) and pro\u2010inflammatory cytokines (Il\u20106 and TNF\u2010\u03b1 secretion) were quantified using THP\u20101 cells in direct contact with films. Hemocompatibility was assessed through haemolysis testing, dynamic blood coagulation, platelet adhesion, and activation (membranous P\u2010selectin expression).<\/jats:p><jats:p>Results show that the different types of COC have successfully passed the <jats:italic>in vitro<\/jats:italic> biocompatibility tests. The presence of antioxidant induces however a slight decrease in ROS production in correlation with a high SOD activity and a modification in blood coagulation profile probably linked to antioxidant recrystallization phenomenon on the surface of COC. The lubricant presence reduced haemolysis, fibrinogen adhesion, and platelet activation.<\/jats:p><jats:p>Surface nanotopography of COC highlights different types of needles and globules according to the present additive. Those primary results indicate that COC are promising biomaterial. However, additives influenced some biological parameters pointing out the necessity of a global approach of risk analysis for biocompatibility evaluation. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 3333\u20133349, 2017.<\/jats:p>","DOI":"10.1002\/jbm.a.36199","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T01:17:25Z","timestamp":1504660645000},"page":"3333-3349","source":"Crossref","is-referenced-by-count":46,"title":["Biocompatibility assessment of cyclic olefin copolymers: Impact of two additives on cytotoxicity, oxidative stress, inflammatory reactions, and hemocompatibility"],"prefix":"10.1002","volume":"105","author":[{"given":"M\u00e9lisande","family":"Bernard","sequence":"first","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"},{"name":"Assistance Publique \u2013 H\u00f4pitaux de Paris, Agence G\u00e9n\u00e9rale des Produits et Equipements de Sant\u00e9, Laboratories Departement Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2855-4091","authenticated-orcid":false,"given":"Emile","family":"Jubeli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joudi","family":"Bakar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Tortolano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Saunier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najet","family":"Yagoubi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Paris\u2010Sud University, EA 401 Groupe Mat\u00e9riaux et Sant\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208101001"},{"key":"e_1_2_7_3_1","unstructured":"ISO 10993 parts 1\u201320: Biological Evaluation of Medical Devices. 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