{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:31Z","timestamp":1786977991220,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF\u20102017R1A2B2003848"],"award-info":[{"award-number":["NRF\u20102017R1A2B2003848"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Insufficient repair of the bone\u2010to\u2010tendon interface (BTI) with structural\/compositional gradients has been a significant challenge in orthopedics. In this study, dual growth factor (platelet\u2010derived growth factor\u2010BB [PDGF\u2010BB] and bone morphogenetic protein\u20102 [BMP\u20102])\u2010immobilized polycaprolactone (PCL)\/Pluronic F127 asymmetrically porous membrane was fabricated to estimate its feasibility as a potential strategy for effective regeneration of BTI injury. The growth factors immobilized (via heparin\u2010intermediated interactions) on the membrane were continuously released for up to \u223c80% of the initial loading amount after 5 weeks without a significant initial burst. From the\n                    <jats:italic>in vivo<\/jats:italic>\n                    animal study using a rat patellar tendon avulsion model, it was observed that the PDGF\u2010BB\/BMP\u20102\u2010immobilized membrane accelerates the regeneration of the BTI injury, probably because of the continuous release of both growth factors (biological stimuli) and their complementary effect to create a multiphasic structure (bone, fibrocartilage, and tendon) like a native structure, as well as the role of the asymmetrically porous membrane as a physical barrier (nanopore side; prevention of fibrous tissue invasion into the defect site) and scaffold (micropore side; guidance for tissue regeneration). \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 115\u2013125, 2018.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.36212","type":"journal-article","created":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T09:36:05Z","timestamp":1504776965000},"page":"115-125","source":"Crossref","is-referenced-by-count":19,"title":["Dual growth factor\u2010immobilized asymmetrically porous membrane for bone\u2010to\u2010tendon interface regeneration on rat patellar tendon avulsion model"],"prefix":"10.1002","volume":"106","author":[{"given":"Joong\u2010Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nanobiomedical Science Dankook University, 119 Dandae Ro Dongnam Gu Cheonan 31116 Republic of Korea"},{"name":"Department of Periodontology, School of Dentistry and Institute of Oral Bioscience Chonbuk National University, 567 Baekjedae Ro Deokjin Gu Jeonju 54896 Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se 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