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Strut surfaces allowing excellent adhesion and migration of endothelial cells and endothelial progenitor cells may accelerate <jats:italic>in\u2010situ<\/jats:italic> re\u2010endothelialization. Here, a well\u2010known endothelial cell adhesive peptide, Arg\u2010Glu\u2010Asp\u2010Val (REDV), was directly immobilized onto metallic surfaces by means of single\u2010step tyrosine oxidation with copper chloride (II) and hydrogen peroxide, which we recently reported as a new biomaterial modification technique. REDV immobilization on a 316L stainless steel plate improved endothelial cell adhesion and effectively suppressed platelet adhesion <jats:italic>in vitro<\/jats:italic>. In addition, a Co\u2010Cr stent immobilized with Ac\u2010Tyr\u2010Gly\u2010Gly\u2010Gly\u2010Arg\u2010Glu\u2010Asp\u2010Val (Y\u2010REDV) was implanted into a rabbit abdominal aorta. On 7 days postimplantation, 80% of the strut surface of the Y\u2010REDV\u2010immobilized stent was covered by a thin neointimal layer and was similar in appearance to native endothelium. Restenosis and late thrombosis were not observed in the Y\u2010REDV\u2010immobilized stent for 42 days. These findings suggest that direct immobilization of Y\u2010REDV peptide onto metallic biomaterials by tyrosine oxidation is effective for promoting <jats:italic>in\u2010situ<\/jats:italic> re\u2010endothelialization in vascular stents. \u00a9 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 491\u2013499, 2018.<\/jats:p>","DOI":"10.1002\/jbm.a.36258","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T10:11:49Z","timestamp":1507111909000},"page":"491-499","source":"Crossref","is-referenced-by-count":24,"title":["Direct surface modification of metallic biomaterials via tyrosine oxidation aiming to accelerate the re\u2010endothelialization of vascular stents"],"prefix":"10.1002","volume":"106","author":[{"given":"Sachiro","family":"Kakinoki","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute, 5\u20107\u20101 Fujishiro\u2010dai Suita Osaka 565\u20108565 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensuke","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute, 5\u20107\u20101 Fujishiro\u2010dai Suita Osaka 565\u20108565 Japan"},{"name":"Faculty of Chemistry, Materials and Bioengineering Kansai University, 3\u20103\u201035 Yamatecho Suita Osaka 565\u20108680 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Mahara","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute, 5\u20107\u20101 Fujishiro\u2010dai Suita Osaka 565\u20108565 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomo","family":"Ehashi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute, 5\u20107\u20101 Fujishiro\u2010dai Suita Osaka 565\u20108565 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Materials and Bioengineering Kansai University, 3\u20103\u201035 Yamatecho Suita Osaka 565\u20108680 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuji","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Cerebral and Cardiovascular Center Research Institute, 5\u20107\u20101 Fujishiro\u2010dai Suita Osaka 565\u20108565 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. 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