{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:31:18Z","timestamp":1773862278886,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:00:00Z","timestamp":1518048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Measurement of the mechanical properties of skin <jats:italic>in vivo<\/jats:italic> has been complicated by the lack of methods that can accurately measure the viscoelastic properties without assuming values of Poisson's ratio and tissue density. In this paper, we present the results of preliminary studies comparing the mechanical properties of skin and scar tissue measured using a technique involving optical cohesion tomography (OCT) and vibrational analysis. This technique has been reported to give values of the modulus that correlate with those obtained from tensile measurements made on decellularized dermis (Shah et al., Skin Res Technol 2016;23:399\u2013406; Shah et al., J Biomed Mater Res Part 2017;105:15\u201322). The high correlation between moduli measured using vibrational studies and uniaxial tensile tests suggest that the modulus can be determined by measuring the natural frequency that occurs when a tissue is vibrated in tension. The results of studies on glutaric anhydride treated decellularized dermis suggest that vibrational analysis is a useful technique to look at changes in the properties of skin that occur after cosmetic and surgical treatments are used. Preliminary results suggest that the resonant frequency of scar tissue is much higher than that of adjacent normal skin reflecting the higher collagen content of scar. OCT in concert with vibrational analysis appears to be a useful tool to evaluate processes that alter skin properties in animals and humans as well to study the onset and pathogenesis of skin diseases such as cancer. This technique may be useful to evaluate the extent of wound healing in skin diabetic ulcers and other chronic skin conditions, scar tissue formation in response to implants, and other therapeutic treatments that alter skin properties. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1421\u20131427, 2018.<\/jats:p>","DOI":"10.1002\/jbm.a.36344","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:45:14Z","timestamp":1516635914000},"page":"1421-1427","source":"Crossref","is-referenced-by-count":11,"title":["Biomechanical analysis of decellularized dermis and skin: Initial <i>in vivo<\/i> observations using optical cohesion tomography and vibrational analysis"],"prefix":"10.1002","volume":"106","author":[{"given":"Ruchit G.","family":"Shah","sequence":"first","affiliation":[{"name":"Graduate Program in Biomedical Engineering Rutgers, The State University of New Jersey Piscataway New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale","family":"DeVore","sequence":"additional","affiliation":[{"name":"DV Consulting Services Chelmsford Massachusetts 01824"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick H.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey Piscataway New Jersey 08854"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Strength of Biological Materials","author":"Yamada H.","year":"1970"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2257-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008208309005612"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-0735-8"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Measurement of mechanical properties of natural and engineered implants","volume":"1","author":"Silver FH","year":"2016","journal-title":"Adv Tissue Eng Regen Med"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12349"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.007001018.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0909-752X.2006.00150.x"},{"key":"e_1_2_7_10_1","volume-title":"Mechanosensing and Mechanochemical Transduction in Extracellular Matrix","author":"Silver FH.","year":"2006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2015.05.023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2004.04.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12274528"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35859"},{"key":"e_1_2_7_15_1","volume-title":"Biological Materials: Structure, Mechanical Properties and Modeling of Soft Tissues","author":"Silver FH.","year":"1987"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.36344","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.36344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:56:01Z","timestamp":1694922961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.36344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,8]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jbm.a.36344"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.36344","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,8]]}}}