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The purpose of this study was to fabricate phosphatidylserine (PS)\u2010containing supported lipid bilayers (SLBs) on a titanium surface to regulate the polarization of macrophages, a critical factor that affects following tissue healing and regeneration. The fluorescent recovery after photobleaching images showed that the percentage of PS had a critical influence on the fluidity, and 20% PS had the highest fluidity. Furthermore, more expanded and elongated cells were observed in the SLB\u2010coated groups. transforming growth factor\u2010\u03b21 and vascular endothelial growth factor, the key cytokine markers of M2 macrophage polarization, were increased in the SLB\u2010coated groups, especially in the 20% PS group. Consistently, cells cultured on the SLB\u2010coated titanium exhibited the distribution of CD206<jats:sup>+<\/jats:sup>, which is a M2 macrophage specific maker. The results of this study demonstrated M2 polarization of macrophages on PS\u2010SLB\u2010coated titanium discs, which suggests the application of PS\u2010SLB as an immune\u2010regulating coating material to improve tissue reactions to dental implants. \u00a9 2018 Wiley Periodicals, Inc. 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