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Some properties of these nanocarriers (NCs), such as surface morphology, structure, surface charge, stability, and biocompatibility, were evaluated by proton nuclear magnetic resonance, dynamic scanning colorimetry, Fourier\u2010transform infrared spectroscopy, dynamic light scattering, atomic force microscopy, critical aggregation concentration, hemolysis test, MTT assay, and lethal dose 50 (LD50). The AFM results showed that the uniform spherical morphology of NCs have an average size of about \u223c60\u2009nm. The drug loading of NCs was about 14.13 and 10.93% for CUR and MTX, respectively. The NCs revealed pH\u2010sensitivity in drug release. The release of drugs from miktoarm\u2010based NCs in neutral pH was lower than in acidic medium because of faster degradation of polymersome in acidic environment. MTT assay results showed that the drug\u2010loaded NCs did not show significant toxicity due to which cell viability maintain over 82% at 300\u2009\u03bcg\/mL concentration. Also, synthesized miktoarm showed hemolysis lower than 3%. This result was repeated in LD50, and all mice which treat with 5000\u2009mg\/kg were still alive after 24\u2009h. These result confirmed safety of miktoarm star copolymer. Eventually, the goal of this study is the application of water\u2010soluble star copolymers miktoarm with pH dependent release properties for designing a new drug delivery carrier and using CUR for enhancing anticancer properties of MTX. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2817\u20132826, 2018.<\/jats:p>","DOI":"10.1002\/jbm.a.36468","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T08:25:35Z","timestamp":1529137535000},"page":"2817-2826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Amphiphilic Y shaped miktoarm star copolymer for anticancer hydrophobic and hydrophilic drugs codelivery: Synthesis, characterization, <i>in vitro<\/i>, and <i>in vivo<\/i> biocompatibility study"],"prefix":"10.1002","volume":"106","author":[{"given":"Mozhgan","family":"Aghajanzadeh","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biomaterials, School of Pharmacy Zanjan University of Medical Sciences  Zanjan Iran"},{"name":"Student Research Center Zanjan University of Medical Sciences  Zanjan 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