{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:41:25Z","timestamp":1773042085651,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,18]],"date-time":"2018-11-18T00:00:00Z","timestamp":1542499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51672088"],"award-info":[{"award-number":["51672088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have successfully prepared a novel targeted drug delivery system, composed of folic acid (FA) as targeting molecule, methotrexate (MTX) as anticancer drug, and bioactive glass (BG) as carrier. The BG nanoparticles were synthesized by sol\u2010gel method with the dodecylamine as template. The surface of BG nanoparticles was grafted with amino groups by (3\u2010aminopropyl) triethoxysilane, then, FA and MTX were covalently conjugated to the surface of modified BG through amidation reaction, so FA functionalized BG (BG\u2010FA) and targeted drug delivery system (MTX\u2010BG\u2010FA) were prepared. The physicochemical properties of BG, BG\u2010NH<jats:sub>2<\/jats:sub>, and BG\u2010FA were characterized by various methods, such as X\u2010ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, ultraviolet\u2013visible, and so on. Moreover, the drug release results showed that the MTX\u2010BG\u2010FA had sustained release property because of the peptide bond between MTX and BG\u2010FA. And the cytocompatibility evaluation demonstrated that the BG and BG\u2010FA were biocompatible and BG\u2010FA even could promote cell proliferation, while the MTX\u2010BG\u2010FA had high cytotoxicity owning to the sustained release of anticancer drug. From the above, it could be concluded that MTX\u2010BG\u2010FA could kill tumor cells targetedly and sustainedly, which made it a good cancer targeted therapy material. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 319\u2013329, 2019.<\/jats:p>","DOI":"10.1002\/jbm.a.36471","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T03:50:27Z","timestamp":1542599427000},"page":"319-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preparation and characterization of folic acid functionalized bioactive glass for targeted delivery and sustained release of methotrexate"],"prefix":"10.1002","volume":"107","author":[{"given":"Jianhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou South China University of Technology  Guangdong China"},{"name":"Key Laboratory of Biomedical Materials and Engineering, Ministry of Education Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou South China University of Technology  Guangdong China"},{"name":"Key Laboratory of Biomedical Materials and Engineering, Ministry of Education Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, School of Materials Science and Engineering Guangzhou South China University of Technology  Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1529"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0093-7754(01)90132-0"},{"key":"e_1_2_6_5_1","first-page":"998","article-title":"Facts and uncertainities in the treatment of soft tissue sarcomas","volume":"22","author":"D\u00fcrr HR","year":"2009","journal-title":"Alcoholism Clin Exp Res"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.023143"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-6-200709180-00178"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/459508a"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2663"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015860525341"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.03.022"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0286(02)00117-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095833"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00044-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.020"},{"key":"e_1_2_6_16_1","first-page":"557","article-title":"Trophoblast and ovarian cancer antigen LK26. 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