{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:23Z","timestamp":1786977983274,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570974"],"award-info":[{"award-number":["31570974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Herein, we fabricated the novel drug delivery system based on the self\u2010assembly of two polyelectrolytes, poly\u2010allylamine hydrochloride (PAH) and fucoidan, as the polycation and polyanion, respectively, under mild conditions for cancer therapeutics. Furthermore, the designed polyelectrolyte complex nanoparticles as well as the methotrexate (MTX) disodium salt\u2010loaded composites were systematically characterized using various techniques. The MTX loading in the nanoparticles was confirmed by zeta potential values that changed from \u221236.2 \u00b1 2.2 to \u221228.3 \u00b1 3.1 mV at a loading amount of 13.3 \u00b1 1.2%. Furthermore, the obtained eventual particle sizes of nanoparticles were various with different concentrations and ratios of polyelectrolytes. The particle size also has increased from 130 \u00b1 2.6 to 162.9 \u00b1 2.3 nm after loading MTX. The drug release investigations\n                    <jats:italic>in vitro<\/jats:italic>\n                    at a pH value of 6.0 (acid environment) showed that the release of MTX was sustained in the conditions provided. Finally, we investigated the anticancer efficacy of MTX\u2010loaded nanoparticles on MCF\u20107 cells and HeLa cells and the satisfactory results were obtained. Together, these self\u2010assembled PAH\/fucoidan nanoparticles with sustained drug release property will become the promising delivery system for cancer therapeutics. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 339\u2013347, 2019.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.36526","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T11:14:10Z","timestamp":1544613250000},"page":"339-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Poly\u2010allylamine hydrochloride and fucoidan\u2010based self\u2010assembled polyelectrolyte complex nanoparticles for cancer therapeutics"],"prefix":"10.1002","volume":"107","author":[{"given":"Pei","family":"Wang","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering Huaqiao University  Xiamen Fujian 361021 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjith Kumar","family":"Kankala","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Huaqiao University  Xiamen Fujian 361021 People's Republic of 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