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The porous grafts were surface\u2010modified through hydrolysis, amination, and nanocrystallization treatment. The surface properties of the modified grafts were characterized by energy dispersive spectroscopy (EDS) and scanning electron microscopy (SEM). The materials were cocultured with bone marrow mesenchymal stem cells (BMSCs). The effect of different pore sizes and surface modifications on the cell proliferation behavior was evaluated by the cell counting kit\u20108 (CCK\u20108). Compared to native tracheas, the PTS has good biomechanical properties. A pore diameter of 200 \u03bcm is the optimum for cell adhesion, and the surface modifications successfully improved the cytotropism of the PTS. Allogeneic implantation confirmed that it largely retains its structural integrity in the host, and the immune rejection reaction of the PTS decreased significantly after the acute phase. Nano\u2010silicon dioxide (NSD)\u2010modified PTS is a promising material for tissue engineering tracheal reconstruction. \u00a9 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 360\u2013370, 2019.<\/jats:p>","DOI":"10.1002\/jbm.a.36536","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:39:06Z","timestamp":1543430346000},"page":"360-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Selection of the optimum 3D\u2010printed pore and the surface modification techniques for tissue engineering tracheal scaffold <i>in vivo<\/i> reconstruction"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9118-3281","authenticated-orcid":false,"given":"Shu","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery The Second Xiangya Hospital, Central South University  Changsha 410011 China"},{"name":"Department of Cardiothoracic Surgery Clinical medical college of Yangzhou University  Yangzhou 225001 China"},{"name":"Key Laboratory of Integrative Medicine in 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