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The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic\u2010based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to produce injectable\/moldable SBSs. Dextrin, a low\u2010molecular\u2010weight carbohydrate, was used to develop a fully resorbable and injectable HG. It was first oxidized with sodium periodate and then cross\u2010linked with adipic acid dihydrazide. The <jats:italic>in vivo<\/jats:italic> biocompatibility and safety of the dextrin\u2010based HG was assessed by subacute systemic toxicity and skin sensitization tests, using rodent models. The results showed that the HG did not induce any systemic toxic effect, skin reaction, or genotoxicity, neither impaired the bone repair\/regeneration process. 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