{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T07:48:42Z","timestamp":1779004122401,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T00:00:00Z","timestamp":1556496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Formation of peritoneal adhesions is common complication after abdominal and pelvic surgery. They bear a significant health problem with an influence to quality of life and health care expenses. Promising approach for their prevention is using of biodegradable barrier films for physical separation of peritoneal surfaces. In the present study, highly porous pectin\u2010based three\u2010dimensional (3D) scaffolds were obtained by freeze\u2010drying technique. Physico\u2010chemical properties of the formed materials, including their morphology, porosity, density, and stability, have been studied. The evaluation of their biocompatibility, biodegradation, and potential antiadhesion effect was studied by in vivo experiment. To reinforce the scaffolds structure and improve their stability in physiological solutions, pectin chains were cross\u2010linked with divalent cations. We determined optimal cross\u2010linking conditions, which allow obtaining scaffolds with desired biodegradation rate. These cross\u2010linked scaffolds fully dissolved within 8 days in the peritoneal cavity with low presence of complications and some antiadhesive effect. It has also been determined that mesenchymal stem cells from adipose tissue could effectively adhere to the scaffolds with preservation of their viability. Our results show that obtained materials can be suggested as mechanical scaffold for delivery of the stem cells culture to peritoneal surfaces as a part of complex antiadhesive barrier system.<\/jats:p>","DOI":"10.1002\/jbm.a.36700","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T10:19:13Z","timestamp":1555928353000},"page":"1814-1823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Fabrication and characterization of pectin\u2010based three\u2010dimensional porous scaffolds suitable for treatment of peritoneal adhesions"],"prefix":"10.1002","volume":"107","author":[{"given":"Viktoryia","family":"Kulikouskaya","sequence":"first","affiliation":[{"name":"The Laboratory of Micro\u2010 and Nano\u2010 Structured Materials Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aliaksandr","family":"Kraskouski","sequence":"additional","affiliation":[{"name":"The Laboratory of Micro\u2010 and Nano\u2010 Structured Materials Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kseniya","family":"Hileuskaya","sequence":"additional","affiliation":[{"name":"The Laboratory of Micro\u2010 and Nano\u2010 Structured Materials Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandr","family":"Zhura","sequence":"additional","affiliation":[{"name":"Belorussian State Medical University  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislau","family":"Tratsyak","sequence":"additional","affiliation":[{"name":"Belorussian State Medical University  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Agabekov","sequence":"additional","affiliation":[{"name":"The Laboratory of Micro\u2010 and Nano\u2010 Structured Materials Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus  Minsk Republic of Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.08.085"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.33066"},{"key":"e_1_2_7_4_1","first-page":"79","article-title":"The clinical application of autologous mesenchymal stem cells isolated from fat tissue for the treatment of patients with trophic ulcers of lower extremities","volume":"8","author":"Baranov E. 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