{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:45:37Z","timestamp":1777567537563,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51562007"],"award-info":[{"award-number":["51562007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The impact of the surface modification on the subcellular distribution of nanoparticles in the brain remains elusive. The nanoparticles prepared by conjugating polyethylene glycol and maleic anhydride\u2010coated superparamagnetic iron oxide nanoparticles (Mal\u2010SPIONs) with bovine serum albumin (BSA\/Mal\u2010SPIONs) and with Arg\u2013Gly\u2013Asp peptide (RGD\/Mal\u2010SPIONs) were injected into the rat substantia nigra. Observation of transmission electron microscopy (TEM) samples obtained 24\u2009h after perfusion showed that abundant RGD\/Mal\u2010SPIONs accumulated in the myelin sheath, dendrites, axon terminals and mitochondria, and on cell membranes in the brain tissue near the injection site. For rats injected with BSA\/Mal\u2010SPIONs, a few nanoparticles accumulated in the myelin sheath, axon terminals, endoplasmic reticulum, mitochondria, Golgi, and lysosomes of neurons and glial cells while least SPIONs in rats injected with Mal\u2010SPIONs were found. TEM pictures showed some Mal\u2010SPIONs were expelled out of the brain. RGD\/Mal\u2010SPIONs diffused extensively to the thalamus, frontal cortex, temporal lobe, olfactory bulb, and brain stem after injection. Only a few BSA\/Mal\u2010SPIONs diffused to the afore\u2010mentioned brain areas. This work reveals different surface modifications on the iron oxide nanoparticles play crucial roles in their distribution and diffusion in the rat brains.<\/jats:p>","DOI":"10.1002\/jbm.a.36711","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T16:09:51Z","timestamp":1557331791000},"page":"1988-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Subcellular distributions of iron oxide nanoparticles in rat brains affected by different surface modifications"],"prefix":"10.1002","volume":"107","author":[{"given":"Sheng","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of New Processing Technology for Nonferrous Metal and Materials, College of Materials Science and Engineering Guilin University of Technology  Guilin China"},{"name":"Guangxi Key Laboratory of Optical and Electronic Materials and Devices, College of Materials Science and Engineering Guilin 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