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In this article, we report on new borophosphate glasses [<jats:italic>x<\/jats:italic>M<jats:sub>n<\/jats:sub>O<jats:sub>m<\/jats:sub>\u2009+\u2009(100\u2009\u2212\u2009<jats:italic>x<\/jats:italic>) (47.5P<jats:sub>2<\/jats:sub>O<jats:sub>5<\/jats:sub>\u2009+\u20092.5B<jats:sub>2<\/jats:sub>O<jats:sub>3<\/jats:sub>\u2009+\u200910Na<jats:sub>2<\/jats:sub>O\u2009+\u200920CaO\u2009+\u200920SrO)], M<jats:sub>n<\/jats:sub>O<jats:sub>m<\/jats:sub>being CuO, Ag<jats:sub>2<\/jats:sub>O, and CeO<jats:sub>2<\/jats:sub>, having high thermal processability, hence suitable for fiber drawing and sintering into scaffolds. Furthermore, the glasses dissolve congruently in simulated body fluid (SBF) and TRIS buffer solution, eventually leading to the precipitation of a reactive layer. Human adipose stem cells (hASC) were cultured in media enriched with glass extract at different dilutions, to investigate the optimal ion concentration for cell survival. Cells grew in all the extracts, except in the undiluted Cu\u2010doped glass extract. At dilution 1:10, the lactate dehydrogenase (LDH) activity and cell proliferation were comparable to the control, while at 1:100, the cells proliferated faster than the control. Thus, the reference (undoped), Ag and Ce\u2010doped glasses were found to be suitable for cell viability and proliferation. Cytotoxicity assessments using the LDH assay indeed revealed the high cytotoxicity of the Cu extract. This raises questions about the use of Cu in bioactive glasses and its optimal concentration as a dopant.<\/jats:p>","DOI":"10.1002\/jbm.a.36722","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T16:43:14Z","timestamp":1557852194000},"page":"2099-2114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["In\u2010vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses"],"prefix":"10.1002","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-8427","authenticated-orcid":false,"given":"Ayush","family":"Mishra","sequence":"first","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Faculty of Medicine and Health Technology and BioMediTech Institute Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miina","family":"Ojansivu","sequence":"additional","affiliation":[{"name":"Adult Stem Cell Group, Faculty of Medicine and Health Technology and BioMediTech Tampere University Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reija","family":"Autio","sequence":"additional","affiliation":[{"name":"Faculty of Social Sciences and BioMediTech Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Vanhatupa","sequence":"additional","affiliation":[{"name":"Adult Stem Cell Group, Faculty of Medicine and Health Technology and BioMediTech Tampere University Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Miettinen","sequence":"additional","affiliation":[{"name":"Adult Stem Cell Group, Faculty of Medicine and Health Technology and BioMediTech Tampere University Finland"},{"name":"Research, Development and Innovation Centre Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Massera","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials and Tissue Engineering, Faculty of Medicine and Health Technology and BioMediTech Institute Tampere University Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.024"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2008.0348"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.solidstatesciences.2011.02.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00547-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30808"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/bglass-2015-0004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3093(94)90333-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2006.02.029"},{"key":"e_1_2_8_10_1","first-page":"283","article-title":"On the nature of yellow coloring in cerium\u2010containing silica glasses","volume":"20","author":"Blinkova G. 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