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Similarly, despite significant efforts to create functional tissue\u2010engineered organs, clinical success is often hindered by insufficient oxygen diffusion and poor vascularization. To overcome these shortcomings, we previously used the oxygen carrier perfluorooctane (PFO) to develop PFO emulsion\u2010loaded hollow microparticles (PFO\u2010HPs). PFO\u2010HPs act as a local oxygen source that increase cell viability and maintains the osteogenic differentiation potency of human periosteum\u2010derived cells (<jats:italic>h<\/jats:italic>PDCs) under hypoxic conditions. In the present study, we used a miniature pig model of mandibular osteomyelitis to investigate bone regeneration using <jats:italic>h<\/jats:italic>PDCs seeded on PFO\u2010HPs (<jats:italic>h<\/jats:italic>PDCs\/PFO\u2010HP) or <jats:italic>h<\/jats:italic>PDCs seeded on phosphate\u2010buffered saline (PBS)\u2010HPs (<jats:italic>h<\/jats:italic>PDCs\/PBS\u2010HP). Osteomyelitis is characterized by a series of microbial invasion, vascular disruption, bony necrosis, and sequestrum formation due to impaired host defense response. Sequential plain radiography, computed tomography (CT), and 3D reconstructed CT images revealed new bone formation was more advanced in defects that had been implanted with the <jats:italic>h<\/jats:italic>PDCs\/PFO\u2010HPs than in defects implanted with the <jats:italic>h<\/jats:italic>PDCs\/PBS\u2010HP. Thus, PFO\u2010HPs are a promising tissue engineering approach to repair challenging bone defects and regenerate structurally organized bone tissue with 3D architecture.<\/jats:p>","DOI":"10.1002\/jbm.a.36728","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T15:33:31Z","timestamp":1558539211000},"page":"2183-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Development of bone regeneration strategies using human periosteum\u2010derived osteoblasts and oxygen\u2010releasing microparticles in mandibular osteomyelitis model of miniature pig"],"prefix":"10.1002","volume":"107","author":[{"given":"Sun\u2010Chul","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Institute of Health Sciences, School of Medicine, Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae 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Gyeongsang National University  Jinju Republic of Korea"},{"name":"The Korean Society of Maxillofacial Aesthetic Surgery  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Hoon","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Institute of Health Sciences, Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu\u2010Jin","family":"Rho","sequence":"additional","affiliation":[{"name":"Department of Theriogenology and Biotechnology College of Veterinary Medicine, Gyeongsang National University  Jinju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon\u2010Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Theriogenology and Biotechnology College of 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