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Their specific surface areas of \u223c57.5 m<jats:sup>2<\/jats:sup>\/g and pore volume of \u223c0.02\u2009cm<jats:sup>3<\/jats:sup>\/g were significantly larger than those of PPy\/PLLA films, due to the addition of C\u2010GO nanosheets. Then, C\u2010GO\/PPy\/PLLA conducting conduit with 2\u2009mm inner diameter was prepared to bridge 10\u2009mm sciatic nerve defect of rats, and the direction of fiber\u2010axis in the conduit was the same as the conduit central axis. Electrical stimulation (ES) of 1 V and 20\u2009Hz through the conducting conduit was exerted on the defect site. The results of in vivo electrophysiological and histological evaluation indicated that, the sciatic nerve defect could be repaired in C\u2010GO\/PPy\/PLLA conduit, moreover the re\u2010innervated gastrocnemius muscle and nerve conduction in C\u2010GO\/PPy\/PLLA conduit &amp; ES group were obviously better than the conduit without ES group. The results of transmission electron microscope analysis also demonstrated that the mean thickness of myelin sheath and diameter of axon in C\u2010GO\/PPy\/PLLA conduit &amp; ES group were significantly larger than those without ES, suggesting that the repair efficiency of ES &amp; conduit group was closer to that of autograft group. These results indicated the great potential of C\u2010GO\/PPy\/PLLA with the in vivo ES in the application of sciatic nerve repair.<\/jats:p>","DOI":"10.1002\/jbm.a.36781","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T15:30:36Z","timestamp":1565710236000},"page":"2784-2795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Preparation of carboxylic graphene oxide\u2010composited polypyrrole conduits and their effect on sciatic nerve repair under electrical stimulation"],"prefix":"10.1002","volume":"107","author":[{"given":"Xianchun","family":"Chen","sequence":"first","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongbing","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Pu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjing","family":"Xue","sequence":"additional","affiliation":[{"name":"Neurosurgery department of Affiliated Hospital of North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB00668B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbon.2013.09.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-07-02602.2000"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.05.056"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-4804(03)00255-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.10.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.susc.2008.07.020"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b12567"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-6779(98)00790-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b01126"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2010.07.004"},{"key":"e_1_2_7_14_1","first-page":"315","article-title":"Data in support of in vivo studies of silk based gold nano\u2010composite conduits for functional peripheral nerve regeneration","volume":"4","author":"Das S.","year":"2015","journal-title":"Biomaterials"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.08.045"},{"issue":"1","key":"e_1_2_7_16_1","first-page":"194","article-title":"Stimulation of neurite outgrowth in a human nerve scaffold designed for peripheral nerve reconstruction","volume":"73","author":"Dumont C. 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