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Current treatment options typically involve the long term, systemic administration of a combination of antibiotics, often followed by implant removal. Here we engineered an injectable hydrogel capable of encapsulating\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    bacteriophage and delivering active phage to the site of bone infections. Bacteriophage retain their bacteriolytic activity after encapsulation and release from the hydrogel, and their rate of release from the hydrogel can be controlled by gel formulation. Bacteriophage\u2010encapsulating hydrogels effectively kill their host bacteria in both planktonic and biofilm phenotypes in vitro without influencing the metabolic activity of human mesenchymal stromal cells. Bacteriophage\u2010encapsulating hydrogels were used to treat murine radial segmental defects infected with\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    . The hydrogels achieved a 4.7\u2010fold reduction in live\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    counts at the infection site compared to bacteriophage\u2010free hydrogels at 7\u2009days postimplantation. These results support the development of bacteriophage\u2010delivering hydrogels to treat local bone infections.\n                  <\/jats:p>","DOI":"10.1002\/jbm.a.36790","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T17:15:00Z","timestamp":1566580500000},"page":"39-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Bacteriophage delivering hydrogels reduce biofilm formation in vitro and infection in vivo"],"prefix":"10.1002","volume":"108","author":[{"given":"James A.","family":"Wroe","sequence":"first","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of Medicine  Atlanta Georgia"},{"name":"Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory University School of Medicine  Atlanta Georgia"},{"name":"Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s J.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology  Atlanta Georgia"},{"name":"Woodruff School of Mechanical Engineering Georgia Institute of Technology  Atlanta 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