{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T04:45:47Z","timestamp":1766551547439,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T00:00:00Z","timestamp":1571011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alveolar bone loss is always a big challenge for oral implant placement. Guided bone regeneration (GBR) is one of the solutions to fix this problem. Among all the factors, the barrier membrane plays a key role in this technology. At present, lack of the osteoinductivity remains the biggest weakness for clinical application. Focusing on this, we tried to fabricate an osteoinductive three\u2010dimensional (3D) nanofiber membrane with drug releasing system by introducing parathyroid hormone (PTH)\u2010Fc into the poly(lactic acid\u2010<jats:italic>co<\/jats:italic>\u2010caprolactone) PLCL\/SF solution for electrospinning. The characteristics were determined by scanning electron microscopy, X\u2010ray diffraction, contact angle measurement, and mechanical strength. According to the optimum parameters tested, we proceed to the in vitro experiments. Drug release and matrix degradation profiles of electrospinning fibers were investigated. Cell morphology was observed and cell proliferation was analyzed after bone marrow mesenchymal stem cells (BMMSCs) were seeded. The results showed favorable physical and chemical properties and good biocompatibility of these 3D nanofibers. The effect on the BMMSCs suggested the drug releasing promoted osteogenic differentiation of cells stably. This study exhibited a promising method of GBR oeteoinductive membrane fabrication. The bone reconstruction will be benefited from the osteogenic differentiation positive drug releasing system.<\/jats:p>","DOI":"10.1002\/jbm.a.36801","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T05:00:18Z","timestamp":1569906018000},"page":"157-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preparation and characteristics of electrospinning PTH\u2010Fc\/PLCL\/SF membranes for bioengineering applications"],"prefix":"10.1002","volume":"108","author":[{"given":"Lihua","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology Shanghai JiaoTong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Department of Implantology School\/Hospital of Stomatology Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Technology, School of Medicine Xi'an International University  Xi'an Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of VIP Dental Care Center of Hangzhou West Dental Hospital  Zhejiang Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoren","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Implantology School\/Hospital of Stomatology Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Implantology School\/Hospital of Stomatology Lanzhou University  Lanzhou Gansu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7799-606X","authenticated-orcid":false,"given":"Hong\u2010Chang","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Implant Dentistry, Shanghai Ninth People's Hospital, College of Stomatology Shanghai JiaoTong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2017.07.197"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"731","article-title":"Enhancement of experimental fracture\u2010healing by systemic administration of recombinant human parathyroid hormone (PTH 1\u201034)","volume":"87","author":"Alkhiary Y. 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