{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:53:01Z","timestamp":1793764381996,"version":"4.6.1"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"am","delay-in-days":356,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000078","name":"Division of Materials Research","doi-asserted-by":"publisher","award":["554835"],"award-info":[{"award-number":["554835"]}],"id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15HL140503"],"award-info":[{"award-number":["R15HL140503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL134613"],"award-info":[{"award-number":["T32HL134613"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number of people affected by heart disease such as coronary artery disease and myocardial infarction increases at an alarming rate each year. Currently, the methods to treat these diseases are restricted to lifestyle change, pharmaceuticals, and eventually heart transplant if the condition is severe enough. While these treatment options are the standard for caring for patients who suffer from heart disease, limited regenerative ability of the heart restricts the effectiveness of treatment and may lead to other heart\u2010related health problems in the future. Because of the increasing need for more effective therapeutic technologies for treating diseased heart tissue, cardiac patches are now a large focus for researchers. The cardiac patches are designed to be integrated into the patients' natural tissue to introduce mechanical support and healing to the damaged areas. As a promising alternative, synthetic biodegradable polymer based biomaterials can be easily manipulated to customize material properties, as well as possess certain desired characteristics for cardiac patch use. This comprehensive review summarizes recent works on synthetic biodegradable cardiac patches implanted into infarcted animal models. In addition, this review describes the basic requirements that should be met for cardiac patch development, and discusses the inspirations to designing new biomaterials and technologies for cardiac patches.<\/jats:p>","DOI":"10.1002\/jbm.a.36874","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T15:15:37Z","timestamp":1577978137000},"page":"972-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Current advances in biodegradable synthetic polymer based cardiac patches"],"prefix":"10.1002","volume":"108","author":[{"given":"Sara","family":"McMahan","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Copeland","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zui","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Innovation University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Texas at Arlington  Arlington Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.05.064"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2019.03.044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000558"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199896"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-011-4259-x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2013.0578"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0205"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.01.108"},{"key":"e_1_2_6_10_1","first-page":"5338","article-title":"Using cell\u2010seeded electrospun patch for myocardial injury: In\u2010vitro and in rat model","volume":"2018","author":"Chen W. L.","year":"2018","journal-title":"Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.02.013"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2875"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ENG.2016.01.028"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.07.039"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2316"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615728114"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.06.085"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.05.006"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.050"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100173-8.00017-X"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2015.09.074"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.10204"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.01.006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.4417"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.11.013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.06.020"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.27760"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv017"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/459465"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.46"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.04.017"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.045"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.11.014"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2009.0130"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.08.017"},{"issue":"4","key":"e_1_2_6_37_1","first-page":"1678","article-title":"Electrospun nanofibrous sheets of collagen\/elastin\/polycaprolactone improve cardiac repair after myocardial infarction","volume":"8","author":"Liu Y.","year":"2016","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.09.038"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10504"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4956"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1290\/0411071.1"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.07.013"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600549"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.02.023"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31578"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2013.04.058"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2014.0265"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rby021"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0028"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.055"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-016-9718-9"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.04.028"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-016-0559-z"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymertesting.2019.02.029"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13097"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0602-602"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.05.009"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b15009"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34451"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35765"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2009.12.033"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30128"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.02.036"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbm.a.36874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.36874","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.36874","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jbm.a.36874","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.36874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:38:37Z","timestamp":1693928317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.36874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,12]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/jbm.a.36874"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.36874","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,12]]},"assertion":[{"value":"2019-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}