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We hypothesized that injection of a thermoresponsive hydrogel, with ROS scavenging properties, into the MI would decrease ROS and improve BZ function. Fourteen sheep underwent antero\u2010apical MI. Seven sheep had a comb\u2010like copolymer synthesized from <jats:italic>N<\/jats:italic>\u2010isopropyl acrylamide (NIPAAm) and 1500\u2009MW methoxy poly(ethylene glycol) methacrylate, (NIPAAm\u2010PEG1500), injected (20\u2009\u00d7\u20090.5 mL) into the MI zone 40\u2009min after MI (MI\u2009+\u2009NIPAAm\u2010PEG1500) and seven sheep were MI controls. Cardiac MRI was performed 2\u2009weeks before and 6\u2009weeks after MI\u2009+\u2009NIPAAm\u2010PEG1500. BZ wall thickness at end systole was significantly higher for MI\u2009+\u2009NIPAAm\u2010PEG1500 (12.32\u2009\u00b1\u20090.51\u2009mm\/m<jats:sup>2<\/jats:sup> MI\u2009+\u2009NIPAAm\u2010PEG1500 vs. 9.88\u2009\u00b1\u20090.30 MI; <jats:italic>p<\/jats:italic>\u2009=\u2009.023). Demembranated muscle force development for BZ myocardium 6\u2009weeks after MI was significantly higher for MI\u2009+\u2009NIPAAm\u2010PEG1500 (67.67\u2009\u00b1\u20092.61\u2009m<jats:italic>N<\/jats:italic>\/m<jats:sup>2<\/jats:sup> MI + NIPAAm\u2010PEG1500 vs. 40.53\u2009\u00b1\u20091.04 MI; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) but not significantly different from remote myocardium or BZ or non\u2010operated controls. Levels of ROS in BZ tissue were significantly lower in the MI\u2009+\u2009NIPAAm\u2010PEG1500 treatment group (hydroxyl <jats:italic>p<\/jats:italic>\u2009=\u2009.0031; superoxide <jats:italic>p<\/jats:italic>\u2009=\u2009.0182). We conclude that infarct injection of the NIPAAm\u2010PEG1500 hydrogel with ROS scavenging properties decreased ROS and improved contractile protein function in the border zone 6\u2009weeks after MI.<\/jats:p>","DOI":"10.1002\/jbm.a.36941","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T06:21:27Z","timestamp":1586413287000},"page":"1736-1746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility"],"prefix":"10.1002","volume":"108","author":[{"given":"Kimberly A.","family":"Spaulding","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-607X","authenticated-orcid":false,"given":"Yang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Materials Science and Engineering University of California at Berkeley  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoaki","family":"Takaba","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusuya","family":"Ramasubramanian","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Materials Science and Engineering University of California at Berkeley  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Badathala","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Haraldsson","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"},{"name":"Department of Anesthesiology, Medicine, Radiology, and Surgery University of California at San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Collins","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Aguayo","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curran","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Materials Science and Engineering University of California at Berkeley  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"},{"name":"Department of Anesthesiology, Medicine, Radiology, and Surgery University of California at San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas P.","family":"Ziats","sequence":"additional","affiliation":[{"name":"Department of Pathology Case Western Reserve University  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Lovett","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center  San Francisco California USA"},{"name":"Department of Anesthesiology, Medicine, Radiology, and Surgery University of California at San Francisco  California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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