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However, the material wear particles released from the surface of prostheses cause prosthetic loosening as a result of aseptic osteolysis in long\u2010term use. Therefore, it is important to find an agent that inhibits the formation and function of osteoclast for therapeutic use. Notch signaling pathway plays a lot of roles in cell proliferation, differentiation, and apoptosis. However, the role of Notch signaling pathway in osteoclastogenesis remains unclear. The aim of this study is to assess the effects of \u03b3\u2010secretase inhibitor DAPT on osteoclastogenesis via Notch signaling pathway in vitro and titanium particle\u2010induced osteolysis in vivo. In animal experiments, the inhibitory effect of DAPT on titanium particle\u2010induced osteolysis in a mouse calvaria model was demonstrated. Interestingly, few resorption pits were observed following administration of DAPT and almost no osteoclasts formed at high concentration of DAPT. in vitro experiments revealed the mechanism of the effects of DAPT on osteoclastogenesis. DAPT inhibited the formation and function of osteoclast by blocking RANKL\u2010induced Notch2\u2010NF\u2010\u03baB complex signaling pathway. In conclusion, these results indicated that DAPT could prevent and cure titanium particle\u2010induced prosthetic loosening and other osteoclast\u2010related diseases.<\/jats:p>","DOI":"10.1002\/jbm.a.36972","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T02:09:50Z","timestamp":1587607790000},"page":"2150-2161","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>DAPT<\/scp> inhibits titanium particle\u2010induced osteolysis by suppressing the <scp>RANKL\/Notch2<\/scp> signaling pathway"],"prefix":"10.1002","volume":"108","author":[{"given":"Xiang","family":"Wei","sequence":"first","affiliation":[{"name":"Shandong Province Key Laboratory of Oral Tissue Regeneration, School of Stomatology Shandong University  Jinan China"},{"name":"Department of Oral and Maxillofacial Surgery, School of Stomatology Shandong University  Jinan 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