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This drug was incorporated into mucoadhesive polymeric inserts prepared using chitosan (Chs) and chondroitin sulfate (CS). Of current interest is the mucoadhesion, which increases the contact time with the ocular surface, resulting in improved bioavailability; also, the inserts are made to act as a prolonged release system. In the present work the inserts were prepared by the solvent casting method using different polymeric proportions (30:70, 50:50, 75:25% w\/w Chs:CS and 100% Chs). Thermal analysis and infrared spectroscopy both demonstrated physical dispersion of the active drug. The most promising was the 50:50% Chs:CS which demonstrated that it was not fragile and has an in vitro release profile of up to 180\u2009minutes. In addition, it presented greater adhesion strength in relation to the other formulations. These physicochemical results corroborate the in vivo tests performed. In this sense, we also demonstrated that the treatment with the 50:50% insert can control the intraocular pressure (IOP) for at least 3\u2009weeks and prevents damage to the retinal ganglion cells (RGCs) compared to the placebo insert. Thus, this indicates thus that the new drug is quite viable and promising in glaucoma treatment.<\/jats:p>","DOI":"10.1002\/jbm.a.37026","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T11:42:43Z","timestamp":1591184563000},"page":"336-345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New antiglaucomatous agent for the treatment of open angle glaucoma: Polymeric inserts for drug release and in vitro and in vivo study"],"prefix":"10.1002","volume":"109","author":[{"given":"Aina Liz A.","family":"Cesar","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Caldeira","family":"Navarro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel Oliveira","family":"Castilho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Assis Castro","family":"Goulart","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Foureaux","sequence":"additional","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson J.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebasti\u00e3o","family":"Cronemberger","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-6158","authenticated-orcid":false,"given":"Andr\u00e9 Augusto","family":"Gomes Faraco","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Minas Gerais  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b13-00724"},{"key":"e_1_2_7_3_1","unstructured":"ANVISA(2007). 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