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The ion substitution showed two mineral groups, the high\u2010calcium containing minerals with a maximum measured molar Ca\/Sr ratio of 80%\/20% (mass ratio 63%\/37%) and the high\u2010strontium containing ones with a maximum measured molar Ca\/Sr ratio of 21%\/79% (mass ratio 10%\/90%). In contrast to the high\u2010strontium mineral phases, a high mass loss was observed for the calcium\u2010based minerals during incubation in cell culture medium (alpha\u2010MEM), but also an increase in strength owing to dissolution and re\u2010precipitation. This resulted for the former in a decrease of cation concentration (Ca\u2009+\u2009Sr) in the medium, while the pH value decreased and the phosphate ion concentration rose significantly. The latter group of materials, the high\u2010strontium containing ones, showed only a moderate change in mass and a decrease in strength, but the Ca\u2009+\u2009Sr concentration remained permanently above the initial calcium concentration in the medium. 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