{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:02:31Z","timestamp":1773198151988,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T00:00:00Z","timestamp":1602460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["AFIRM W81XWH\u201008\u20102\u20100034"],"award-info":[{"award-number":["AFIRM W81XWH\u201008\u20102\u20100034"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["CDMRP\/JPC8\u2010CRMRP W81XWH\u201016\u20101\u20100796"],"award-info":[{"award-number":["CDMRP\/JPC8\u2010CRMRP W81XWH\u201016\u20101\u20100796"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["JWMRP W81XWH\u201014\u20101\u20100100"],"award-info":[{"award-number":["JWMRP W81XWH\u201014\u20101\u20100100"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["MRMC W81XWH\u201015\u20101\u20100466"],"award-info":[{"award-number":["MRMC W81XWH\u201015\u20101\u20100466"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EB001046"],"award-info":[{"award-number":["EB001046"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Promising biomaterials should be tested in appropriate large animal models that recapitulate human inflammatory and regenerative responses. Previous studies have shown tyrosine\u2010derived polycarbonates (TyrPC) are versatile biomaterials with a wide range of applications across multiple disciplines. The library of TyrPC has been well studied and consists of thousands of polymer compositions with tunable mechanical characteristics and degradation and resorption rates that are useful for nerve guidance tubes (NGTs). NGTs made of different TyrPCs have been used in segmental nerve defect models in small animals. The current study is an extension of this work and evaluates NGTs made using two different TyrPC compositions in a 1 cm porcine peripheral nerve repair model. We first evaluated a nondegradable TyrPC formulation, demonstrating proof\u2010of\u2010concept chronic regenerative efficacy up to 6 months with similar nerve\/muscle electrophysiology and morphometry to the autograft repair control. Next, we characterized the acute regenerative response using a degradable TyrPC formulation. After 2\u2009weeks in vivo, TyrPC NGT promoted greater deposition of pro\u2010regenerative extracellular matrix (ECM) constituents (in particular collagen I, collagen III, collagen IV, laminin, and fibronectin) compared to commercially available collagen\u2010based NGTs. This corresponded with dense Schwann cell infiltration and axon extension across the lumen. These findings confirmed results reported previously in a mouse model and reveal that TyrPC NGTs were well tolerated in swine and facilitated host axon regeneration and Schwann cell infiltration in the acute phase across segmental defects \u2010 likely by eliciting a favorable neurotrophic ECM milieu. This regenerative response ultimately can contribute to functional recovery.<\/jats:p>","DOI":"10.1002\/jbm.a.37110","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T07:25:25Z","timestamp":1601277925000},"page":"1183-1195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tyrosine\u2010derived polycarbonate nerve guidance tubes elicit proregenerative extracellular matrix deposition when used to bridge segmental nerve defects in swine"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5361-9224","authenticated-orcid":false,"given":"Justin C.","family":"Burrell","sequence":"first","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurotrauma, Neurodegeneration &amp; Restoration Corporal Michael J. Crescenz Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"},{"name":"Department of Bioengineering, School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Bhatnagar","sequence":"additional","affiliation":[{"name":"New Jersey Center for Biomaterials Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan P.","family":"Brown","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurotrauma, Neurodegeneration &amp; Restoration Corporal Michael J. Crescenz Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2324-5874","authenticated-orcid":false,"given":"N. Sanjeeva","family":"Murthy","sequence":"additional","affiliation":[{"name":"New Jersey Center for Biomaterials Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Dutton","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D.","family":"Browne","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurotrauma, Neurodegeneration &amp; Restoration Corporal Michael J. Crescenz Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco A.","family":"Laimo","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurotrauma, Neurodegeneration &amp; Restoration Corporal Michael J. Crescenz Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zarina S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center, Division of Plastic Surgery Dartmouth College  Lebanon New Hampshire USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilton M.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"New Jersey Center for Biomaterials Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Kohn","sequence":"additional","affiliation":[{"name":"New Jersey Center for Biomaterials Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-5216","authenticated-orcid":false,"given":"D. Kacy","family":"Cullen","sequence":"additional","affiliation":[{"name":"Center for Brain Injury &amp; Repair, Department of Neurosurgery, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Neurotrauma, Neurodegeneration &amp; Restoration Corporal Michael J. Crescenz Veterans Affairs Medical Center  Philadelphia Pennsylvania USA"},{"name":"Department of Bioengineering, School of Engineering and Applied Science University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000335650.09473.D3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevBiomedEng.v39.i2.20"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/micr.30133"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-201202000-00001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.02.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.07.056"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.08.040"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.08.089"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2041731416629471"},{"issue":"3","key":"e_1_2_9_11_1","first-page":"518","article-title":"Enhanced femoral nerve regeneration after tubulization with a tyrosine\u2010derived polycarbonate terpolymer: effects of protein adsorption and independence of conduit porosity","volume":"20","author":"Ezra M","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2015.0354"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5889-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-015-5558-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa106"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0jm00868k"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201600133"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00105-8"},{"key":"e_1_2_9_19_1","first-page":"14","volume-title":"Principles, Characterization, and Processing","author":"Murthy NS","year":"2016"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00492"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.12.030"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1558944715627233"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90123-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(98)00018-0"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30941"},{"key":"e_1_2_9_26_1","first-page":"405","article-title":"Peripheral nerve conduits: technology update","volume":"7","author":"Arslantunali D","year":"2014","journal-title":"Med Devices (Auckl)"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91014-X"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0516-1"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294509"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2013-0022"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20740"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(94)90049-3"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(10)80027-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01997.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3055291"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"593","article-title":"Schwann cell extracellular matrix molecules and their receptors","volume":"15","author":"Chernousov MA","year":"2000","journal-title":"Histol Histopathol"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.2987"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1997.6650"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw068"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90146-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.5.SPINE161100"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201701164"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.3171\/FOC.2009.26.2.E5"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00084-X"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.11.036"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbm.a.37110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jbm.a.37110","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:59:04Z","timestamp":1693555144000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,12]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/jbm.a.37110"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37110","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.01.11.902007","asserted-by":"object"}]},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,12]]},"assertion":[{"value":"2020-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}