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Therefore, we used combination of epothilone B (EpoB) and rapamycin (Rap) to analyze the cytotoxic effect against breast cancer cells (MCF\u20107; MDA\u2010MB\u2010231). Also, the effect of drugs co\u2010delivered in bioresorbable micelles functionalized with biotin (PLA\u2013PEG\u2010BIO; poly(lactide)\u2010co\u2010poly(ethylene glycol)\u2010biotin) was studied. The comparison of effects of the mixture of free drugs and the micelles co\u2010loaded with EpoB and Rap revealed a significant decrease in the cell metabolic activity and survival. Moreover, the dual drug\u2010loaded PLA\u2013PEG\u2010BIO micelles enhanced the cytotoxicity of EpoB and Rap against the tested cells as compared with the free drugs. The blank PLA\u2013PEG\u2010BIO micelles did not affect the tested cells. We expect that mixture of EpoB and Rap may be promising in breast cancer treatment and PLA\u2013PEG\u2010BIO micelles as carrier of these two drugs can be applicable for successful targeted delivery.<\/jats:p>","DOI":"10.1002\/jbm.a.37164","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T07:30:16Z","timestamp":1615793416000},"page":"1693-1700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytotoxic effect of targeted biodegradable epothilone B and rapamycin co\u2010loaded nanocarriers on breast cancer cells"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3016-3444","authenticated-orcid":false,"given":"Alicja","family":"Zajdel","sequence":"first","affiliation":[{"name":"Department of Biopharmacy Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland  Sosnowiec 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