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Wear particles induce a prolonged upregulation of nuclear factor kappa B (NF\u2010\u03baB) signaling in macrophages and osteoclasts. Synthetic double\u2010stranded oligodeoxynucleotides (ODNs) can prevent the binding of NF\u2010\u03baB to the promoter regions of targeted genes and inhibit genetic activation. We tested the hypothesis that polyethylene\u2010particle induced chronic inflammatory bone loss could be suppressed by local delivery of NF\u2010\u03baB decoy ODNs in murine in vivo model. Polyethylene particles were continuously infused into the medullary cavity of the distal femur for 6\u2009weeks to induce chronic inflammation, and micro\u2010computational tomography and immunohistochemical analysis were performed. Particle\u2010induced chronic inflammation resulted in lower BMD values, an increase in osteoclastogenesis and nuclear translocation of p65, a prolonged M1 pro\u2010inflammatory macrophage phenotype, and a decrease of M2 anti\u2010inflammatory macrophage phenotype. Delayed timing of local infusion of NF\u2010\u03baB decoy ODN for the last 3\u2009weeks reversed polyethylene\u2010particle associated chronic inflammatory bone loss and facilitated bone healing. This study demonstrated that polyethylene\u2010particle associated chronic inflammatory osteolysis can be effectively modulated via interference with the NF\u2010\u03baB pathway; this minimally invasive intervention could potentially be an efficacious therapeutic strategy for periprosthetic osteolysis after TJA.<\/jats:p>","DOI":"10.1002\/jbm.a.37175","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T05:45:46Z","timestamp":1616996746000},"page":"1828-1839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Suppression of <scp>NF\u2010\u03baB<\/scp>\u2010induced chronic inflammation mitigates inflammatory osteolysis in the murine continuous polyethylene particle infusion model"],"prefix":"10.1002","volume":"109","author":[{"given":"Takeshi","family":"Utsunomiya","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Stanford University  Stanford California 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