{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:44Z","timestamp":1786977944228,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extracellular vesicles from adipose derived stem cells (ADSCs\u2010EVs) have shown immunomodulation and anti\u2010photoaging effects; however, the skin barrier prevents their absorption via skin. Meanwhile, microneedle (MN) is a widely used and minimally invasive tool for dermal delivery of drugs, it also has neocollagenesis effect by creating tiny injuries and initiating wound healing process. To investigate the effect of MN combined with ADSCs\u2010EVs on skin aging, photoaging in SKH\u20101 mice was induced by chronic exposure to ultraviolet radiation. Then the mice were treated following a split\u2010dorsal scheme, in which one side had MN alone or MN\u2009+\u2009EVs treatment and the other side was left untreated. For the side treated with MN alone or MN\u2009+\u2009EVs, the epidermal thickness was decreased and the skin barrier function was enhanced compared with the untreated side. However, MN\u2009+\u2009EVs group showed the least wrinkles, the highest collagen density and the most organized collagen fibers among the three groups. The level of CD11b\u2009+\u2009cell infiltration was lower in MN\u2009+\u2009EVs group than that in the MN group at 3\u2009day after the treatment. These results indicated that MN treatment alone could improve epidermal structure and function of photoaging skin, and a combination with ADSCs\u2010EVs would accelerate the restoration of inflammation caused by MN and improve the content of collagen. In all, this study indicated that a combination of MN and topical applied ADSCs\u2010EVs was a feasible and safe strategy to ameliorate photoaging, providing a new avenue for safe administration of EVs.<\/jats:p>","DOI":"10.1002\/jbm.a.37177","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T18:27:38Z","timestamp":1622572058000},"page":"1849-1857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Microneedle based adipose derived stem cells\u2010derived extracellular vesicles therapy ameliorates\n                    <scp>UV<\/scp>\n                    \u2010induced photoaging in\n                    <scp>SKH<\/scp>\n                    \u20101 mice"],"prefix":"10.1002","volume":"109","author":[{"given":"Zhi","family":"Cao","sequence":"first","affiliation":[{"name":"Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine Tongji University  Shanghai 200092 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