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In the blood plasma IONP are getting covered with an albumin crown, so it was decided to test this shell for biocompatibility. Male Wistar rats were anesthetized and underwent laparotomy. Abdominal aorta was connected to external hemodynamic loop with regulated blood flow. Hind body quarter got step\u2010like blood flow changing from 30 to 150\u2009mmHg and back. This was followed with i.v. injection of IONP, albumin solution or albumin\u2010covered IONP and consequent similar flow changes. Central hemodynamics\u2014heart rate and mean arterial pressure were registered throughout the experiment and no significant changes in these parameters were observed. Hind paw microcirculation level had the same dynamic in all groups under changing blood flow conditions. At the end, venous blood was collected for endothelin\u20101 and NO evaluation that showed similar changes and no endothelial damage. Mesenteric arteries and femoral artery reactivity were evaluated with wire myography. Mesenteric arteries had the most relaxing function preservation after albumin\u2010covered IONP injection. Given data reveal advantage of albumin\u2010coated IONP so this can be used for further investigations as a vascular\u2010safe vehicle.<\/jats:p>","DOI":"10.1002\/jbm.a.37193","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T18:26:48Z","timestamp":1617474408000},"page":"2017-2026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Albumin covering maintains endothelial function upon magnetic iron oxide nanoparticles intravenous injection in rats"],"prefix":"10.1002","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-7868","authenticated-orcid":false,"given":"Yana G.","family":"Toropova","sequence":"first","affiliation":[{"name":"Bioprosthetics and Cardioprotection Research Lab V.A. 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