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This work presents an alkaline treatment method to fabricate open\u2010porous poly (lactic\u2010co\u2010glycolic acid) microspheres (OPMs) as bone marrow stromal cells (BMSCs) carriers for cartilage regeneration. OPMs have better biodegradation property and the extended pores can provide easier access for cells to the internal space. The BMSCs cultured with OPMs can display enhanced cell proliferation, up\u2010regulated expression of cartilage\u2010related mRNAs and proteins, and improved cartilage regeneration in vitro and in vivo. These results highlight the advantage and potential of using OPMs fabricated via simple alkaline treatment as injectable stem cell carriers for cartilage regeneration through minimally invasive procedures.<\/jats:p>","DOI":"10.1002\/jbm.a.37196","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T19:16:51Z","timestamp":1618773411000},"page":"2091-2100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Injectable open\u2010porous <scp>PLGA<\/scp> microspheres as cell carriers for cartilage regeneration"],"prefix":"10.1002","volume":"109","author":[{"given":"Moyuan","family":"Qu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University  Chengdu Sichuan China"},{"name":"Stomatology Hospital, School of Stomatology, School of Medicine, Key Laboratory of 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