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Here, we investigated lower molecular weight poly\u2010lactic acid co\u2014epsilon\u2010caprolactone (PLA\u2010CL) formulations with varying molecular weight and film casting concentrations as potential matrices for the therapeutic delivery of biologics in the rotator cuff. Matrices were fabricated with target footprint dimensions to facilitate controlled and protected release of model biologic (Bovine Serum Albumin), and anatomically\u2010unhindered implantation under the acromion in a rodent model of acute rotator cuff repair. The matrix obtained from the highest polymeric\u2010film casting concentration showed a controlled release of model biologics payload. The tested matrices rapidly degraded during the initial 4\u2009weeks due to preferential hydrolysis of the lactide\u2010rich regions within the polymer, and subsequently maintained a stable molecular weight due to the emergence of highly\u2010crystalline caprolactone\u2010rich regions. pH evaluation in the interior of the matrix showed minimal change signifying lesser accumulation of acidic degradation byproducts than seen in other bulk\u2010degrading polymers, and maintenance of conformational stability of the model biologic payload. The context\u2010dependent biocompatibility evaluation in a rodent model of acute rotator cuff repair showed matrix remodeling without eliciting excessive inflammatory reaction and is anticipated to completely degrade within 6\u00a0months. The engineered PLA\u2010CL matrices offer unique advantages in controlled and protected biologic delivery, non\u2010toxic biodegradation, and biocompatibility overcoming several limitations of commonly\u2010used biodegradable polyesters.<\/jats:p>","DOI":"10.1002\/jbm.a.37200","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T18:49:36Z","timestamp":1620758976000},"page":"2137-2153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Kinetic degradation and biocompatibility evaluation of <scp>polycaprolactone\u2010based<\/scp> biologics delivery matrices for regenerative engineering of the rotator cuff"],"prefix":"10.1002","volume":"109","author":[{"given":"Anupama","family":"Prabhath","sequence":"first","affiliation":[{"name":"Connecticut Convergence Institute for Translation in Regenerative Engineering UConn Health  Farmington Connecticut USA"},{"name":"Department of Orthopaedic 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