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Herein, a kind of multipurpose PATGP@PDA\u2009+\u2009Ag microspheres was prepared via emulsion method by using a conductive aniline tetramer (AT) substituted polyphosphazene (PATGP), followed by polydopamine (PDA) modification and silver nanoparticles (AgNPs) loading. The PATGP@PDA\u2009+\u2009Ag microspheres demonstrated a strong antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> both in vitro and in vivo, while showing no cytotoxicity at an optimized AgNPs loading amount. Due to the electron\u2010donor structure of the AT moieties, the PATGP@PDA\u2009+\u2009Ag microspheres displayed antioxidant capacities to scavenge reactive oxygen species (ROS). Due to their phosphorus\u2010rich feature, the PATGP@PDA\u2009+\u2009Ag microspheres favored the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). As controls, nonconductive microspheres (PAGP@PDA, PAGP@PDA\u2009+\u2009Ag) were prepared similarly by using poly[(ethylalanine)(ethylglycyl)]phosphazene (PAGP). By co\u2010implanting these microspheres with <jats:italic>S. aureus<\/jats:italic> into rat calvarial defects, among them, it was determined that the PATGP@PDA\u2009+\u2009Ag microspheres achieved the most abundant neo\u2010bone formation, benefiting from their antibacterial, antioxidant and osteogenic activities. These results revealed that AgNPs loaded scaffolds made of conductive polyphosphazenes were promising for the regeneration of infected bone defects.<\/jats:p>","DOI":"10.1002\/jbm.a.37252","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T10:17:25Z","timestamp":1624702645000},"page":"2580-2596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antibacterial, conductive, and osteocompatible polyorganophosphazene microscaffolds for the repair of infectious calvarial defect"],"prefix":"10.1002","volume":"109","author":[{"given":"Yiqian","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organic\u2010Inorganic Composites, Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing 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