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However, the traditional glutaraldehyde cross\u2010linked BHVs fail within 12\u201315\u2009years mainly due to leaflet tear and calcification defects. In this study, a novel visible light\u2013induced cross\u2010linking of the porcine pericardium (PP) was realized by the photo\u2010oxidation of the furfuryl\u2010modified PP in the presence of Rose Bengal. The resulting material showed comparable collagen stability with the glutaraldehyde cross\u2010linked PP and appropriate biomechanical properties such as tensile strength, modulus, and elongation, suggesting that this material could meet the general requirement for BHVs. Besides, this cross\u2010linked PP showed significantly improved cytocompatibility compared with the Glut\u2013cross\u2010linked PP, with no cytotoxicity to L929 cells and the ability to support HUVECgrowth. Meanwhile, this material showed superior anti\u2010tearing performance and much less calcification than the Glut\u2013cross\u2010linked PP in hope of reducing the risk of BHV failure. Considering these results, the visible light\u2013induced cross\u2010linking method proposed in this study could provide a promising way to construct a biocompatible and robust biomaterial for the fabrication of the BHV.<\/jats:p>","DOI":"10.1002\/jbm.a.37263","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T05:11:51Z","timestamp":1625893911000},"page":"31-42","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Visible light\u2013induced cross\u2010linking of porcine pericardium for the improvement of endothelialization, anti\u2010tearing, and anticalcification properties"],"prefix":"10.1002","volume":"110","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Biomaterials Sichuan University  Chengdu 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