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To reduce this complication, we developed a decyl group (C10)\u2010modified Alaska pollock gelatin (ApGltn) (C10\u2010ApGltn) sealant and evaluated its practical performance against commercially available sealants, Beriplast\u00ae and DuraSeal\u00ae. C10\u2010ApGltn was synthesized by reductive amination of the amino groups in ApGltn with decanal. C10\u2010ApGltn was crosslinked with a poly(ethylene glycol)\u2010based crosslinker to form a tissue sealant. The crosslinking time of the C10\u2010ApGltn sealant was fast enough for curing on tissue and application as a spray system. Although the percent swelling of C10\u2010ApGltn and DuraSeal was significantly greater than Beriplast, C10\u2010ApGltn and DuraSeal exhibited excellent tissue sealing properties on pleura tissue under a long\u2010term moist condition. Additionally, C10\u2010ApGltn and DuraSeal did not cause severe inflammatory responses in a rat subcutaneous example. 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