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This problem is further amplified by drug\u2010resistant pathogens that might invade or evolve under these conditions. Furthermore, currently available bone cements are incompatible with some antibiotics. The proposed device resembles conventional bone cement beads but contains an on\u2010demand drug delivery magnetic sponge that provides actively controlled release of antibiotics. The slightly porous structure facilitates some drug diffusion while further drug release may be controlled remotely via magnetic actuation. Additionally, a combination of silver nitrate and gentamicin are used in the device as these agents are shown to display a synergistic antibacterial activity in vitro using checkerboard and time\u2010kill assays. The device releases gentamicin and silver in both actuation and diffusion modes over 7\u2009days. The in vitro bacterial studies demonstrate the efficacy of the released agents alone, and synergistically in combination, against Methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic>. The proposed device offers a facile fabrication process which allows control of the release profile by engineering hole configurations or manipulating magnetic field strength to provide the most effective therapy.<\/jats:p>","DOI":"10.1002\/jbm.a.37350","type":"journal-article","created":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T10:40:00Z","timestamp":1641638400000},"page":"1036-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Controlled and localized antibiotics delivery using <scp>magnetic\u2010responsive<\/scp> beads for synergistic treatment of orthopedic infection"],"prefix":"10.1002","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-8563","authenticated-orcid":false,"given":"Ali","family":"Shademani","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Chiao","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119421344"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S181198"},{"key":"e_1_2_9_4_1","unstructured":"Centers for Disease Control and Prevention.National Diabetes Statistics Report 2020. 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