{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:43:13Z","timestamp":1783723393093,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Foreign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation and subsequent fibrosis during FBR seems to be affected by recipient immunity, such as the balance of T helper (Th) response that has the potential to regulate FBR\u2010related macrophage function. Here, the immunological effects of FBR on subcutaneously imbedded silicone tubes (ST) at 8\u2009weeks were investigated histologically by comparing Th1\u2010biased C57BL\/6N, Th2\u2010biased MRL\/MpJ, and autoimmune disease\u2010prone MRL\/MpJ\u2010<jats:italic>Fas<\/jats:italic><jats:sup><jats:italic>lpr\/lpr<\/jats:italic><\/jats:sup><jats:italic>.<\/jats:italic> Tissue surrounding ST (TSS) was analyzed at day (D) 7 and 14 (reaction phase) or D35 (stability phase) after surgery. In all strains, the TSS was composed of a thin layer (TL) containing fibrous tissues and loose connective tissues formed outside the TL. Few lymphocytes and mast cells, several neutrophils, and numerous macrophages infiltrated the TSS. Active vascularization was observed at D14 in all strains. For the examined indices, M1\u2010type macrophage density in the TSS of C57BL\/6N mice was significantly higher at D14 compared to other strains. No significant strain difference relating to M2\u2010type macrophages was detected, suggesting the effects of Th1\u2010biased immunity on FBR\u2010related inflammation. Collagen fibers in the TSS increased in density and became stable with age in all strains. In particular, MRL\/MpJ\u2010<jats:italic>Fas<\/jats:italic><jats:sup><jats:italic>lpr\/lpr<\/jats:italic><\/jats:sup> showed progressive fibrotic features. Serum autoantibody levels in MRL\/MpJ\u2010<jats:italic>Fas<\/jats:italic><jats:sup><jats:italic>lpr\/lpr<\/jats:italic><\/jats:sup> mice were inversely correlated with M1\u2010type macrophage density. These data from MRL\/MpJ\u2010<jats:italic>Fas<\/jats:italic><jats:sup><jats:italic>lpr\/lpr<\/jats:italic><\/jats:sup> mice suggested modifications of FBR\u2010related inflammation and fibrosis by autoimmune abnormalities. The results provide crucial insights into the pathological modification of FBR by recipient immunity and emphasize its clinicopathological importance in humans and animals.<\/jats:p>","DOI":"10.1002\/jbm.a.37425","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T10:53:31Z","timestamp":1656586411000},"page":"1921-1931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions"],"prefix":"10.1002","volume":"110","author":[{"given":"Tomohiro","family":"Yamakawa","sequence":"first","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-1554","authenticated-orcid":false,"given":"Osamu","family":"Ichii","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"},{"name":"Laboratory of Agrobiomedical Science, Faculty of Agriculture Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"},{"name":"Department of Biological Safety Research, Chitose Laboratory Japan Food Research Laboratories  Chitose Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Namba","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser Hosny Ali","family":"Elewa","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"},{"name":"Department of Histology, Faculty of Veterinary Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Abdul","family":"Masum","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Physiology, Faculty of Animal Science and Veterinary Medicine Sher\u2010e\u2010Bangla Agricultural University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Otani","sequence":"additional","affiliation":[{"name":"Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine Hokkaido University  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Laboratory of Agrobiomedical Science, Faculty of Agriculture Hokkaido University  Sapporo Japan"},{"name":"Laboratory of Cell and Tissue Biology, Research Faculty of Agriculture Hokkaido University  Sapporo 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