{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:48:53Z","timestamp":1774331333039,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11972161"],"award-info":[{"award-number":["11972161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51875214"],"award-info":[{"award-number":["51875214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue engineering (TE) scaffolds with appropriate Poisson's ratio (PR) are suitable for mimicking the environment of native tissues on which cells could survive and thrive better. Herein, cellular structured scaffolds are made by a new composite poly(ethylene glycol) diacrylate\/cellulose nanofibril aerogel, with prototypes of the hexagonal, reentrant, and semireentrant models. Scaffolds with different geometry parameters (<jats:italic>l<\/jats:italic>, <jats:italic>t<\/jats:italic>, <jats:italic>\u03b1<\/jats:italic>) are designed and simulated by COMSOL to enable precise regulation of their PR. Then, nine groups of scaffolds with different PRs ranging from \u22120.5 to 0.85 are designed by adjusting geometry parameters and fabricated by using stereolithography and freeze\u2010drying techniques. Subsequently, bone marrow mesenchymal stem cells (BMSc) are cultured on these scaffolds for 21\u2009days, during which CCK8 assay, fluorescence microscope observation, and real\u2010time polymerase chain reaction experiments are performed to characterize the proliferation and differentiation of BMSc. The results reflect that the scaffolds with different PR can provide various stress environments for cells, and the scaffold with zero PR is the most suitable for BMSc differentiating into chondrocytes during early culture experiments. This study suggests that tuning PR precisely is an attractive and effective strategy to provide a cells\u2010suitable environment for scaffold fabrication for TE.<\/jats:p>","DOI":"10.1002\/jbm.a.37468","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:31:05Z","timestamp":1667903465000},"page":"502-513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tuning the Poisson's ratio of poly(ethylene glycol) diacrylate\/cellulose nanofibril aerogel scaffold precisely for cultivation of bone marrow mesenchymal stem cell"],"prefix":"10.1002","volume":"111","author":[{"given":"Dong","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory of Materials Processing and Die &amp; Mould Technology, School of Materials Science and Engineering Huazhong University of Science and Technology  Wuhan 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