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We used scandium (Sc; 2\u00a0wt\u00a0%) and strontium (Sr; 2\u00a0wt\u00a0%) as alloying elements due to their high biocompatibility, antibacterial efficacy, osteogenesis, and protective effects against corrosion. In the present work, we also examined the effect of a heat treatment process on the properties of the Mg\u2010Sc\u2010Sr alloy. Alloys were manufactured using a metal casting process followed by heat treatment. The microstructure, corrosion, mechanical properties, antibacterial activity, and osteogenic activity of the alloy were assessed in vitro. The results showed that the incorporation of Sc and Sr elements controlled the corrosion, reduced the hydrogen generation, and enhanced mechanical properties. Furthermore, alloying with Sc and Sr demonstrated a significantly enhanced antibacterial activity and decreased biofilm formation compared to control Mg. Also, culturing Mg\u2010Sc\u2010Sr alloy with human bone marrow\u2010derived mesenchymal stromal cells showed a high degree of biocompatibility (&gt;90% live cells) and a significant increase in osteoblastic differentiation in vitro shown by Alizarin red staining and alkaline phosphatase activity. Based on these results, the Mg\u2010Sc\u2010Sr alloy heat\u2010treated at 400\u00b0C displayed optimal mechanical properties, corrosion rate, antibacterial efficacy, and osteoinductivity. These characteristics make the Mg\u2010Sc\u2010Sr alloy a promising candidate for biodegradable orthopedic implants in the fixation of bone fractures such as bone plate\u2010screws or intramedullary nails.<\/jats:p>","DOI":"10.1002\/jbm.a.37476","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T05:16:50Z","timestamp":1670649410000},"page":"556-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications"],"prefix":"10.1002","volume":"111","author":[{"given":"Nadia","family":"Aboutalebianaraki","sequence":"first","affiliation":[{"name":"Biionix\u2122 (Bionic Materials, Implants &amp; Interfaces) Cluster, Department of Internal Medicine, College of Medicine University of Central Florida  Orlando Florida USA"},{"name":"Department of Materials Science and Engineering University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zeblisky","sequence":"additional","affiliation":[{"name":"Biionix\u2122 (Bionic Materials, Implants &amp; Interfaces) Cluster, Department of Internal Medicine, College of Medicine University of Central Florida  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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