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Currently, how to retain regional concentration and decrease rapid diffusion is critical for its clinical application of VEGF. In recent years, the application of targeting peptides has been developed rapidly and provides new strategies for the sustained release of VEGF. In present study, a bi\u2010functional EBP\u2010PR1P peptide was designed and bridged VEGF to injectable cardiac extracellular matrix (c\u2010ECM). Through EBP\u2010PR1P peptides, VEGF could specifically bind with c\u2010ECM to realize the sustained release, without impacting the bioactivity of VEGF. Then VEGF\/EBP\u2010PR1P\/c\u2010ECM scaffolds were constructed and administrated into rats with MI. The results showed VEGF\/EBP\u2010PR1P\/c\u2010ECM could promote angiogenesis, protect cardiomyocytes survival against apoptosis, and improve the recovery of cardiac function. In addition, the mechanism of EBP\u2010PR1P\/VEGF was also investigated which canonical downstream of VEGF\u2010Akt signaling pathway was activated. These results showed specific VEGF\/EBP\u2010PR1P\/c\u2010ECM scaffolds served as promising delivery system for VEGF that facilitated the functional recovery of MI.<\/jats:p>","DOI":"10.1002\/jbm.a.37483","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:21:25Z","timestamp":1672312885000},"page":"995-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional recovery of myocardial infarction by specific <scp>EBP\u2010PR1P<\/scp> peptides bridging injectable cardiac extracellular matrix and vascular endothelial growth factor"],"prefix":"10.1002","volume":"111","author":[{"given":"Wenxuan","family":"Cao","sequence":"first","affiliation":[{"name":"School of Basic Medicine Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery 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