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Wound dehydration hinders wound healing due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species and matrix metalloproteases that impede cell recruitment, extracellular matrix reconstruction, and angiogenesis. Dressings are currently selected based on the relative amount of wound exudate with no universal dressing available that can maintain appropriate wound moisture balance to enhance healing. This work aimed to develop a high porosity poly(ethylene glycol) diacrylate hydrogel foam that can both rapidly remove exudate and provide self\u2010tuning moisture control to prevent wound dehydration. A custom foaming device was used to vary hydrogel foam porosity from 25% to 75% by adjusting the initial air\u2010to\u2010solution volume ratio. Hydrogel foams demonstrated substantial improvements in water uptake volume and rate as compared to bulk hydrogels while maintaining similar hydration benefits with slow dehydration rates. The hydrogel foam with the highest porosity (~75%) demonstrated the greatest water uptake and rate, which outperformed commercial dressing products, Curafoam\u00ae and Silvercel\u00ae, in water absorption, moisture retention, and exudate management. Investigation of the water vapor transmission rates of each dressing at varied hydration levels was characterized and demonstrated the dynamic moisture\u2010controlling capability of the hydrogel foam dressing. Overall, the self\u2010tuning moisture control of this hydrogel foam dressing holds great promise to improve healing outcomes for both dry and exudative chronic wounds.<\/jats:p>","DOI":"10.1002\/jbm.a.37498","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T03:45:38Z","timestamp":1672976738000},"page":"465-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["High porosity\n                    <scp>PEG<\/scp>\n                    \u2010based hydrogel foams with self\u2010tuning moisture balance as chronic wound dressings"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-137X","authenticated-orcid":false,"given":"Ziyang","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The University of Texas at Austin  Austin Texas 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