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The peripheral nervous system may not rehabilitate the harmed regions following disabling disorders, which reduce the quality of life of patients. Fortunately, in recent years, hydrogels have been proposed as exogenous alternatives to bridge damaged nerve stumps to create a useful microenvironment for advancing nerve recovery. However, hydrogel\u2010based medicine in the therapy of peripheral nerve injury still needs a lot of improvement. In this study, GelMA\/PEtOx hydrogel was used for the first time to deliver 4\u2010Aminopyridine (4\u2010AP) small molecules. 4\u2010AP is a broad\u2010spectrum potassium channel blocker, which has been demonstrated to increase neuromuscular function in patients with various demyelinating disorders. The prepared hydrogel showed a porosity of 92.2\u00a0\u00b1\u20092.6% after 20\u2009min, swelling ratio of 456.01\u2009\u00b1\u20092.0% after 180\u2009min, weight loss of 81.7\u00a0\u00b1\u20093.1% after 2\u2009weeks, and good blood compatibility as well as sustainable drug release. MTT analysis was performed to assess the cell viability of the hydrogel and proved that the hydrogel is an appropriate substrate for the survival of cells. In vivo studies were performed for functional analysis and the sciatic functional index (SFI) as well as hot plate latency results showed that the use of GelMA\/PEtOx+4\u2010AP hydrogel enhances the regeneration compared to the GelMA\/PEtOx hydrogel and the control group.<\/jats:p>","DOI":"10.1002\/jbm.a.37514","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T10:40:40Z","timestamp":1676889640000},"page":"1243-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sciatic nerve injury regeneration in adult male rats using gelatin methacrylate (<scp>GelMA<\/scp>)\/poly(2\u2010ethy\u20102\u2010oxazoline) (<scp>PEtOx<\/scp>) hydrogel containing <scp>4\u2010aminopyridine<\/scp> (<scp>4\u2010AP<\/scp>)"],"prefix":"10.1002","volume":"111","author":[{"given":"Saba","family":"Nemati Mahand","sequence":"first","affiliation":[{"name":"Department of Polymer Engineering, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Jahanmardi","sequence":"additional","affiliation":[{"name":"Department of Polymer Engineering, Science and Research Branch Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0659-0238","authenticated-orcid":false,"given":"Benjamin","family":"Kruppke","sequence":"additional","affiliation":[{"name":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein Ali","family":"Khonakdar","sequence":"additional","affiliation":[{"name":"Max Bergmann Center of Biomaterials and Institute of Materials Science Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Department of Polymer Processing Iran Polymer and Petrochemical Institute  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