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Hydrogel injection molding requires that hydrogel polymers have sufficiently delayed crosslinking times to enable injection and molding prior to gelation. In this work, we explore the feasibility of injection molding synthetic poly(ethylene) glycol (PEG)\u2010based hydrogels functionalized with strain promoted azide\u2010alkyne cycloaddition click chemistry functional groups. We evaluate the mechanical properties of a PEG\u2010based hydrogel library, including time to gelation and successful generation of complex geometries via injection molding. We evaluate the binding and retention of adhesive ligand RGD within the library matrices and characterize the viability and function of encapsulated cells. This work demonstrates the feasibility of injection molding synthetic PEG\u2010based hydrogels for tissue engineering applications, with potential utility in the clinic and biomanufacturing.<\/jats:p>","DOI":"10.1002\/jbm.a.37523","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T07:37:44Z","timestamp":1677829064000},"page":"814-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Engineering synthetic poly(ethylene) glycol\u2010based hydrogels compatible with injection molding biofabrication"],"prefix":"10.1002","volume":"111","author":[{"given":"Sarah R.","family":"Brady","sequence":"first","affiliation":[{"name":"School of Biological and Health Systems Engineering Arizona State University  Tempe Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone B.","family":"Gohsman","sequence":"additional","affiliation":[{"name":"School of Biological and 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