{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T08:16:47Z","timestamp":1774167407934,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK124267"],"award-info":[{"award-number":["R01DK124267"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK132387"],"award-info":[{"award-number":["R01DK132387"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biomedical Materials Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inter\u2010particle secondary crosslinks allow microporous annealed particle (MAP) hydrogels to be formed. Methods to introduce secondary crosslinking networks\u00a0in MAP hydrogels include particle jamming, annealing with covalent bonds, and reversible noncovalent interactions. Here, we investigate the effect of two different approaches to secondary crosslinking of polyethylene glycol (PEG) microgels via reversible guest\u2010host interactions. We generated a dual\u2010particle MAP\u2010PEG hydrogel using two species of PEG microgels, one functionalized with the guest molecule, adamantane, and the other with the host molecule, \u03b2\u2010cyclodextrin (Inter\u2010MAP\u2010PEG). In a different approach, a mono\u2010particle MAP\u2010PEG hydrogel was generated using one species of microgel functionalized with both guest and host molecules (Intra\u2010MAP\u2010PEG). The Intra\u2010MAP\u2010PEG formed a homogenous distribution due to the single type of microgels used. We then compared the mechanical properties of these two types of MAP\u2010PEG hydrogels and found that Intra\u2010MAP\u2010PEG resulted in significantly softer gels with lower yield stress. We investigated the effect of intra\u2010particle guest\u2010host interactions through titrated weight percentage and the concentration of functional groups added to the hydrogel. We found that there was an ideal concentration of guest\u2010host molecules that enables intra\u2010 and inter\u2010particle guest\u2010host interactions with sufficient covalent crosslinking. Based on these studies, Intra\u2010MAP\u2010PEG provides a homogeneous guest\u2010host hydrogel that is shear\u2010thinning with reversible secondary crosslinking.<\/jats:p>","DOI":"10.1002\/jbm.a.37540","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T13:30:34Z","timestamp":1680528634000},"page":"1379-1389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Single versus dual microgel species for forming guest\u2010host microporous annealed particle<scp>PEG\u2010MAL<\/scp>hydrogel"],"prefix":"10.1002","volume":"111","author":[{"given":"Adrienne E.","family":"Widener","sequence":"first","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abilene","family":"Roberts","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8666-805X","authenticated-orcid":false,"given":"Edward A.","family":"Phelps","sequence":"additional","affiliation":[{"name":"J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-019-0148-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901391"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201801046"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705912"},{"issue":"22","key":"e_1_2_10_6_1","article-title":"Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs","volume":"1742","author":"Caprio ND","year":"2022","journal-title":"Acta Biomater"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4294"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01499K"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202201115"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2018.11.001"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/anbr.202200030"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201700254"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB00715G"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119725"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900520"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901229"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.07.052"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm05216k"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201800281"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8TB02339E"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22151"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm401280z"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-102015-9.00010-1"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26092412"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.5b00483"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201103574"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.1c01752"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.06720.x"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198596608.001.0001","volume-title":"Elementary Fluid Dynamics","author":"Acheson DJ","year":"1990"},{"key":"e_1_2_10_30_1","article-title":"Biorheological model on flow of Herschel\u2010Bulkley fluid through a tapered arterial stenosis with dilatation","volume":"2015","author":"Priyadharshini S","year":"2015","journal-title":"Appl Bion Biomech"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.05.053"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"}],"container-title":["Journal of Biomedical Materials Research Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbm.a.37540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T04:26:43Z","timestamp":1702182403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbm.a.37540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/jbm.a.37540"],"URL":"https:\/\/doi.org\/10.1002\/jbm.a.37540","archive":["Portico"],"relation":{},"ISSN":["1549-3296","1552-4965"],"issn-type":[{"value":"1549-3296","type":"print"},{"value":"1552-4965","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}